TY - JOUR
T1 - Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation
T2 - A report of 5 cases and review of the literature
AU - Ray, Wilson Z.
AU - Blackburn, Spiros L.
AU - Casavilca-Zambrano, Sandro
AU - Barrionuevo, Carlos
AU - Orrego, Jose E.
AU - Heinicke, Hugo
AU - Dowling, Joshua L.
AU - Perry, Arie
PY - 2009
Y1 - 2009
N2 - Dysembryoplastic neuroepithelial tumors (DNETs) have traditionally been viewed as benign "quasihamartomatous" tumors widely considered curable with surgery alone. More recently, case reports have described malignant gliomas arising after irradiation and recurrences following subtotal or even gross total resection. Herein, we describe five cases of DNET with recurrences 2-7 years after resection. Although the radiology was often alarming (e.g., new ring enhancing mass), the pathology remained benign in most cases. Nonetheless, a probably radiation induced anaplastic astrocytoma was encountered in one case 7 years after therapy. These findings suggest that these patients may need closer follow-up than initially suggested, lending further support to the notion that this tumor behaves more like a benign neoplasm, rather than a dysplastic or hamartomatous lesion.
AB - Dysembryoplastic neuroepithelial tumors (DNETs) have traditionally been viewed as benign "quasihamartomatous" tumors widely considered curable with surgery alone. More recently, case reports have described malignant gliomas arising after irradiation and recurrences following subtotal or even gross total resection. Herein, we describe five cases of DNET with recurrences 2-7 years after resection. Although the radiology was often alarming (e.g., new ring enhancing mass), the pathology remained benign in most cases. Nonetheless, a probably radiation induced anaplastic astrocytoma was encountered in one case 7 years after therapy. These findings suggest that these patients may need closer follow-up than initially suggested, lending further support to the notion that this tumor behaves more like a benign neoplasm, rather than a dysplastic or hamartomatous lesion.
KW - Dysembryoplastic neuroepithelial tumor
KW - Malignant transformation
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=68949110161&partnerID=8YFLogxK
U2 - 10.1007/s11060-009-9849-9
DO - 10.1007/s11060-009-9849-9
M3 - Article
C2 - 19267228
AN - SCOPUS:68949110161
SN - 0167-594X
VL - 94
SP - 283
EP - 292
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 2
ER -