Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis

Adeline S.L. Ng; Joel Kramer; Alejandro Centurion; Josep Dalmau; Eric Huang; Jennifer A. Cotter; Michael D. Geschwind

doi:10.1016/j.jneuroim.2015.08.009

Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis

Adeline S.L. Ng
, Joel Kramer
, Alejandro Centurion
, Josep Dalmau
, Eric Huang
, Jennifer A. Cotter
, Michael D. Geschwind

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Autoantibodies associated with autoimmune limbic encephalitis (ALE) have been well-characterized, with intracellular neuronal antibodies being less responsive to immunotherapy than antibodies to cell surface antigens. Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain. Antibodies to AK5 had been previously identified but were not known to be associated with human disease prior to the report of two patients with AK5-related ALE (Tuzun et al., 2007). We present the complete clinical picture for one of these patients and the first reported neuropathology for AK5 ALE.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	287
DOIs	https://doi.org/10.1016/j.jneuroim.2015.08.009
State	Published - Oct 15 2015

Keywords

Adenylate kinase 5
Autoimmunity
Limbic encephalitis
Neuronal antibodies
Rapidly progressive dementia

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10.1016/j.jneuroim.2015.08.009

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title = "Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis",

abstract = "Autoantibodies associated with autoimmune limbic encephalitis (ALE) have been well-characterized, with intracellular neuronal antibodies being less responsive to immunotherapy than antibodies to cell surface antigens. Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain. Antibodies to AK5 had been previously identified but were not known to be associated with human disease prior to the report of two patients with AK5-related ALE (Tuzun et al., 2007). We present the complete clinical picture for one of these patients and the first reported neuropathology for AK5 ALE.",

keywords = "Adenylate kinase 5, Autoimmunity, Limbic encephalitis, Neuronal antibodies, Rapidly progressive dementia",

author = "Ng, \{Adeline S.L.\} and Joel Kramer and Alejandro Centurion and Josep Dalmau and Eric Huang and Cotter, \{Jennifer A.\} and Geschwind, \{Michael D.\}",

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doi = "10.1016/j.jneuroim.2015.08.009",

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T1 - Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis

AU - Ng, Adeline S.L.

AU - Kramer, Joel

AU - Centurion, Alejandro

AU - Dalmau, Josep

AU - Huang, Eric

AU - Cotter, Jennifer A.

AU - Geschwind, Michael D.

PY - 2015/10/15

Y1 - 2015/10/15

N2 - Autoantibodies associated with autoimmune limbic encephalitis (ALE) have been well-characterized, with intracellular neuronal antibodies being less responsive to immunotherapy than antibodies to cell surface antigens. Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain. Antibodies to AK5 had been previously identified but were not known to be associated with human disease prior to the report of two patients with AK5-related ALE (Tuzun et al., 2007). We present the complete clinical picture for one of these patients and the first reported neuropathology for AK5 ALE.

AB - Autoantibodies associated with autoimmune limbic encephalitis (ALE) have been well-characterized, with intracellular neuronal antibodies being less responsive to immunotherapy than antibodies to cell surface antigens. Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain. Antibodies to AK5 had been previously identified but were not known to be associated with human disease prior to the report of two patients with AK5-related ALE (Tuzun et al., 2007). We present the complete clinical picture for one of these patients and the first reported neuropathology for AK5 ALE.

KW - Adenylate kinase 5

KW - Autoimmunity

KW - Limbic encephalitis

KW - Neuronal antibodies

KW - Rapidly progressive dementia

UR - https://www.scopus.com/pages/publications/84943275107

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DO - 10.1016/j.jneuroim.2015.08.009

M3 - Article

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SP - 31

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis

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Keywords

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