Clinically significant response to zolpidem in disorders of consciousness secondary to anti-N-methyl-d-aspartate receptor encephalitis in a teenager: A case report

Merveen Appu, Michael Noetzel

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background Anti-N-methyl-d-aspartate receptor encephalitis has been associated with a prolonged neuropsychiatric phase that may last for months to years. Patient We report the case of a 16-year-old girl who was diagnosed with anti-N-methyl-d-aspartate receptor encephalitis resulting from left ovarian mature teratoma 2 weeks after presentation with psychosis. Following tumor removal and immunotherapy, recovery from a minimally conscious state was accelerated significantly by zolpidem that was used for her sleep disturbance. Our patient was discharged home 8 weeks after admission with marked improvement in her neurological function. Zolpidem has been reported to improve arousal in disorders of consciousness but there are no previous reports of its benefit among patients with anti-N-methyl-d-aspartate receptor encephalitis. Conclusion Zolpidem would be a reasonable consideration as an adjunctive treatment in anti-N-methyl-d-aspartate receptor encephalitis after tumor removal and immunotherapy to accelerate recovery and rehabilitation.

Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalPediatric Neurology
Volume50
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • anti-N-methyl-d-aspartate receptor encephalitis
  • disorders of consciousness
  • minimally conscious state
  • neurorehabilitation
  • zolpidem

Fingerprint

Dive into the research topics of 'Clinically significant response to zolpidem in disorders of consciousness secondary to anti-N-methyl-d-aspartate receptor encephalitis in a teenager: A case report'. Together they form a unique fingerprint.

Cite this