Abstract
Background Anti-N-methyl-d-aspartate receptor encephalitis has been associated with a prolonged neuropsychiatric phase that may last for months to years. Patient We report the case of a 16-year-old girl who was diagnosed with anti-N-methyl-d-aspartate receptor encephalitis resulting from left ovarian mature teratoma 2 weeks after presentation with psychosis. Following tumor removal and immunotherapy, recovery from a minimally conscious state was accelerated significantly by zolpidem that was used for her sleep disturbance. Our patient was discharged home 8 weeks after admission with marked improvement in her neurological function. Zolpidem has been reported to improve arousal in disorders of consciousness but there are no previous reports of its benefit among patients with anti-N-methyl-d-aspartate receptor encephalitis. Conclusion Zolpidem would be a reasonable consideration as an adjunctive treatment in anti-N-methyl-d-aspartate receptor encephalitis after tumor removal and immunotherapy to accelerate recovery and rehabilitation.
| Original language | English |
|---|---|
| Pages (from-to) | 262-264 |
| Number of pages | 3 |
| Journal | Pediatric Neurology |
| Volume | 50 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2014 |
Keywords
- anti-N-methyl-d-aspartate receptor encephalitis
- disorders of consciousness
- minimally conscious state
- neurorehabilitation
- zolpidem