TY - JOUR
T1 - Clinical utility of type 1 growth factor receptor expression in colon cancer
AU - Leung, Sher Ping
AU - Griffith, Obi L.
AU - Masoudi, Hamid
AU - Gown, Allen
AU - Jones, Steven
AU - Phang, Terry
AU - Wiseman, Sam M.
N1 - Funding Information:
S.M.W. is a Michael Smith Scholar and this work was supported by the Michael Smith Foundation For Health Research and a grant from the St. Paul's Hospital Foundation. O.L.G. was supported by the Canadian Institutes of Health Research and the Michael Smith Foundation For Health Research. S.J.M.J. was supported by the Michael Smith Foundation For Health Research and the British Columbia Cancer Foundation.
PY - 2008/5
Y1 - 2008/5
N2 - Background: To evaluate the expression pattern and prognostic significance of the type 1 growth factor receptor (T1GFR) family in colon carcinoma. Methods: Tissue microarrays were constructed using 127 tumor samples and 47 metastatic lymph nodes and T1GFR family expression was determined by immunohistochemistry. Univariate and multivariate analyses examined clinicopathologic variables for prognostic significance, and the correlation between primary and lymph node expression was determined by Spearman correlation. Results: Overexpression of HER-1, HER-2, HER-3, and HER-4 in tumor samples was 32%, 1%, 12%, and 37%, respectively, and 30%, 0%, 11%, and 24% in nodal samples, respectively. On multivariate analysis, positive margins, lymphatic invasion, and HER-3 expression were significant predictors of survival outcome. There was significant correlation between tumor and regional lymph node expression for the T1GFR family members. Tumor HER-3 expression was associated with lymphatic invasion and distant recurrence. Conclusions: Tumor HER-3 expression has prognostic utility in individuals with colon carcinoma. Correlation between tumor and lymph node expression of T1GFR family members suggests that tumor receptor status may guide targeted therapy selection.
AB - Background: To evaluate the expression pattern and prognostic significance of the type 1 growth factor receptor (T1GFR) family in colon carcinoma. Methods: Tissue microarrays were constructed using 127 tumor samples and 47 metastatic lymph nodes and T1GFR family expression was determined by immunohistochemistry. Univariate and multivariate analyses examined clinicopathologic variables for prognostic significance, and the correlation between primary and lymph node expression was determined by Spearman correlation. Results: Overexpression of HER-1, HER-2, HER-3, and HER-4 in tumor samples was 32%, 1%, 12%, and 37%, respectively, and 30%, 0%, 11%, and 24% in nodal samples, respectively. On multivariate analysis, positive margins, lymphatic invasion, and HER-3 expression were significant predictors of survival outcome. There was significant correlation between tumor and regional lymph node expression for the T1GFR family members. Tumor HER-3 expression was associated with lymphatic invasion and distant recurrence. Conclusions: Tumor HER-3 expression has prognostic utility in individuals with colon carcinoma. Correlation between tumor and lymph node expression of T1GFR family members suggests that tumor receptor status may guide targeted therapy selection.
KW - Colon cancer
KW - HER-1
KW - HER-2
KW - HER-3
KW - HER-4
KW - Tissue microarray
KW - Type 1 growth factor receptor family
UR - http://www.scopus.com/inward/record.url?scp=42049116067&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2007.12.032
DO - 10.1016/j.amjsurg.2007.12.032
M3 - Article
C2 - 18424279
AN - SCOPUS:42049116067
SN - 0002-9610
VL - 195
SP - 604
EP - 610
JO - American journal of surgery
JF - American journal of surgery
IS - 5
ER -