Clinical trials of new and novel therapeutic agents

Arthur E. Baue, Rodney M. Durham, John E. Mazuski

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Throughout this issue of World Journal of Surgery are recommendations and descriptions of therapy to prevent the development of multiple organ failure (MOF). The subjects include advances in monitoring; circulatory, pulmonary, and gut support; blood treatment; immune modulation; and control of the inflammatory process. Additional methods of organ support include recommendations for resuscitation and initial care and for early definitive operations. New therapeutic agents such as growth factors, glucan, ketaconazole, and antithrombin III are described. Finally, methods to support organ function before it fails (circulation, lungs, and kidneys) are described.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalWorld journal of surgery
Issue number4
StatePublished - 1996


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