Clinical strategies to enhance nerve regeneration in composite tissue allotransplantation.

Simone W. Glaus, Philip J. Johnson, Susan E. Mackinnon

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Reinnervation of a hand transplant ultimately dictates functional recovery but provides a significant regenerative challenge. This article highlights interventions to enhance nerve regeneration through acceleration of axonal regeneration or augmentation of Schwann cell support and discuss their relevance to composite tissue allotransplantation. Surgical techniques that may be performed at the time of transplantation to optimize intrinsic muscle recovery--including appropriate alignment of ulnar nerve motor and sensory components, transfer of the distal anterior interosseous nerve to the recurrent motor branch of the median nerve, and prophylactic release of potential nerve entrapment points--are also presented. Copyright Â

Original languageEnglish
Pages (from-to)495-509, ix
JournalHand clinics
Volume27
Issue number4
DOIs
StatePublished - Nov 2011

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