TY - JOUR
T1 - Clinical review
T2 - Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults
AU - Finfer, Simon
AU - Wernerman, Jan
AU - Preiser, Jean Charles
AU - Cass, Tony
AU - Desaive, Thomas
AU - Hovorka, Roman
AU - Joseph, Jeffrey I.
AU - Kosiborod, Mikhail
AU - Krinsley, James
AU - Mackenzie, Iain
AU - Mesotten, Dieter
AU - Schultz, Marcus J.
AU - Scott, Mitchell G.
AU - Slingerland, Robbert
AU - Van den Berghe, Greet
AU - Van Herpe, Tom
N1 - Funding Information:
SF receives research funding and travel expenses to employer from GluMetrics Inc., provision of equipment for research to employer from Dipylon Medical (Eirus), travel expenses and consulting fees to his employer from Edwards Life Sciences, and provision of equipment for research to employer from Nova Biomedical (StatStrip). JW received project funding from CMA, a company that no longer exists which previously developed a device for intravenous microdialysis for glucose monitoring. JP receives speaker and consultancy fees from Edwards Life Sciences, Medtronic and Optiscan. RH reports having received speaker honoraria from Minimed Medtronic, Lifescan, Eli Lilly, and Novo Nordisk, serving on advisory panel for Animas and Minimed Medtronic, receiving license fees from BBraun and Beckton Dickinson, and having served as a consultant to BBraun and Profil. These companies may have patents/ patent applications in the field. RH has two patent applications in the related eldfi . JJ receives funding to the University for clinical trial, advisory board, and travel to speak at meetings from Medtronic MiniMed, Edwards Lifescience, Echo Therapeutics, GluMetrics. JJ receives funding for laboratory studies from Hospira Inc. and Animas-Johnson & Johnson. JJ receives funding to the University for advisory board from Diramos. JJ receives funding to the University for consulting from Teleex. MK rl eceives research funding from American Heart Association, Medtronic MiniMed, GluMetrics, Genentech, Sanofi-Aventis, Gilead, and has served as a consultant for Medtronic MiniMed, GluMetrics, Genentech, Gilead, Boehringer-Ingleheim, and Hoff man-La Roche. JK performs consulting work for Medtronic, Edwards Life Sciences, Roche Diagnostics, and Glysure Ltd. DM received a lecture fee and travel reimbursement from Medtronic during the ESICM 2011 meeting which was paid to the University’s Research Fund. MS receives funding to the institution for consulting work from Medtronic Inc., Glysure Ltd., Roche Diagnostics, Edwards Life Sciences, and Optiscan Biomedical. MS’s institution receives research funding from Medtronic Inc. and Optiscan Biomedical. MGS performs consulting work for Roche Diagnostics, and Edwards Life Sciences. GVdB receives a consulting fee from Glysure Ltd. TC, TD, IM, RS, and TVH declare they have no conflicts of interest.
PY - 2013/6/14
Y1 - 2013/6/14
N2 - The management reporting and assessment of glycemic control lacks standardization. The use of different methods to measure the blood glucose concentration and to report the performance of insulin treatment yields major disparities and complicates the interpretation and comparison of clinical trials. We convened a meeting of 16 experts plus invited observers from industry to discuss and where possible reach consensus on the most appropriate methods to measure and monitor blood glucose in critically ill patients and on how glycemic control should be assessed and reported. Where consensus could not be reached, recommendations on further research and data needed to reach consensus in the future were suggested. Recognizing their clear conflict of interest, industry observers played no role in developing the consensus or recommendations from the meeting. Consensus recommendations were agreed for the measurement and reporting of glycemic control in clinical trials and for the measurement of blood glucose in clinical practice. Recommendations covered the following areas: How should we measure and report glucose control when intermittent blood glucose measurements are used? What are the appropriate performance standards for intermittent blood glucose monitors in the ICU? Continuous or automated intermittent glucose monitoring - methods and technology: can we use the same measures for assessment of glucose control with continuous and intermittent monitoring? What is acceptable performance for continuous glucose monitoring systems? If implemented, these recommendations have the potential to minimize the discrepancies in the conduct and reporting of clinical trials and to improve glucose control in clinical practice. Furthermore, to be fit for use, glucose meters and continuous monitoring systems must match their performance to fit the needs of patients and clinicians in the intensive care setting.
AB - The management reporting and assessment of glycemic control lacks standardization. The use of different methods to measure the blood glucose concentration and to report the performance of insulin treatment yields major disparities and complicates the interpretation and comparison of clinical trials. We convened a meeting of 16 experts plus invited observers from industry to discuss and where possible reach consensus on the most appropriate methods to measure and monitor blood glucose in critically ill patients and on how glycemic control should be assessed and reported. Where consensus could not be reached, recommendations on further research and data needed to reach consensus in the future were suggested. Recognizing their clear conflict of interest, industry observers played no role in developing the consensus or recommendations from the meeting. Consensus recommendations were agreed for the measurement and reporting of glycemic control in clinical trials and for the measurement of blood glucose in clinical practice. Recommendations covered the following areas: How should we measure and report glucose control when intermittent blood glucose measurements are used? What are the appropriate performance standards for intermittent blood glucose monitors in the ICU? Continuous or automated intermittent glucose monitoring - methods and technology: can we use the same measures for assessment of glucose control with continuous and intermittent monitoring? What is acceptable performance for continuous glucose monitoring systems? If implemented, these recommendations have the potential to minimize the discrepancies in the conduct and reporting of clinical trials and to improve glucose control in clinical practice. Furthermore, to be fit for use, glucose meters and continuous monitoring systems must match their performance to fit the needs of patients and clinicians in the intensive care setting.
UR - http://www.scopus.com/inward/record.url?scp=84879028957&partnerID=8YFLogxK
U2 - 10.1186/cc12537
DO - 10.1186/cc12537
M3 - Review article
C2 - 23767816
AN - SCOPUS:84879028957
SN - 1364-8535
VL - 17
JO - Critical Care
JF - Critical Care
IS - 3
M1 - 229
ER -