TY - JOUR
T1 - Clinical resting-state fMRI in the preoperative setting are we ready for prime time?
AU - Lee, Megan H.
AU - Miller-Thomas, Michelle M.
AU - Benzinger, Tammie L.
AU - Marcus, Daniel S.
AU - Hacker, Carl D.
AU - Leuthardt, Eric C.
AU - Shimony, Joshua S.
N1 - Publisher Copyright:
©2016 Wolters Kluwer Health, Inc.
PY - 2016
Y1 - 2016
N2 - The purpose of this manuscript is to provide an introduction to resting-state functional magnetic resonance imaging (RS-fMRI) and to review the current application of this new and powerful technique in the preoperative setting using our institute's extensive experience. RS-fMRI has provided important insights into brain physiology and is an increasingly important tool in the clinical setting. As opposed to task-based functional MRI wherein the subject performs a task while being scanned, RS-fMRI evaluates low-frequency fluctuations in the blood oxygen level dependent (BOLD) signal while the subject is at rest. Multiple resting state networks (RSNs) have been identified, including the somatosensory, language, and visual networks, which are of primary importance for presurgical planning. Over the past 4 years, we have performed over 300 RS-fMRI examinations in the clinical setting and these have been used to localize eloquent somatosensory and language cortices before brain tumor resection. RS-fMRI is particularly useful in this setting for patients who are unable to cooperate with the task-based paradigm, such as young children or those who are sedated, paretic, or aphasic. Although RS-fMRI is still investigational, our experience indicates that this method is ready for clinical application in the presurgical setting.
AB - The purpose of this manuscript is to provide an introduction to resting-state functional magnetic resonance imaging (RS-fMRI) and to review the current application of this new and powerful technique in the preoperative setting using our institute's extensive experience. RS-fMRI has provided important insights into brain physiology and is an increasingly important tool in the clinical setting. As opposed to task-based functional MRI wherein the subject performs a task while being scanned, RS-fMRI evaluates low-frequency fluctuations in the blood oxygen level dependent (BOLD) signal while the subject is at rest. Multiple resting state networks (RSNs) have been identified, including the somatosensory, language, and visual networks, which are of primary importance for presurgical planning. Over the past 4 years, we have performed over 300 RS-fMRI examinations in the clinical setting and these have been used to localize eloquent somatosensory and language cortices before brain tumor resection. RS-fMRI is particularly useful in this setting for patients who are unable to cooperate with the task-based paradigm, such as young children or those who are sedated, paretic, or aphasic. Although RS-fMRI is still investigational, our experience indicates that this method is ready for clinical application in the presurgical setting.
KW - Brain tumor
KW - FMRI
KW - Resting-state FMRI
UR - http://www.scopus.com/inward/record.url?scp=84959221228&partnerID=8YFLogxK
U2 - 10.1097/RMR.0000000000000075
DO - 10.1097/RMR.0000000000000075
M3 - Review article
C2 - 26848556
AN - SCOPUS:84959221228
SN - 0899-3459
VL - 25
SP - 11
EP - 17
JO - Topics in Magnetic Resonance Imaging
JF - Topics in Magnetic Resonance Imaging
IS - 1
ER -