TY - JOUR
T1 - Clinical relevance of terminal Schwann cells
T2 - An overlooked component of the neuromuscular junction
AU - Santosa, Katherine B.
AU - Keane, Alexandra M.
AU - Jablonka-Shariff, Albina
AU - Vannucci, Bianca
AU - Snyder-Warwick, Alison K.
N1 - Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/7
Y1 - 2018/7
N2 - The terminal Schwann cell (tSC), a type of nonmyelinating Schwann cell, is a significant yet relatively understudied component of the neuromuscular junction. In addition to reviewing the role tSCs play on formation, maintenance, and remodeling of the synapse, we review studies that implicate tSCs in neuromuscular diseases including spinal muscular atrophy, Miller–Fisher syndrome, and amyotrophic lateral sclerosis, among others. We also discuss the importance of these cells on degeneration and regeneration after nerve injury. Knowledge of tSC biology may improve our understanding of disease pathogenesis and help us identify new and innovative therapeutic strategies for the many patients who suffer from neuromuscular disorders and nerve injuries.
AB - The terminal Schwann cell (tSC), a type of nonmyelinating Schwann cell, is a significant yet relatively understudied component of the neuromuscular junction. In addition to reviewing the role tSCs play on formation, maintenance, and remodeling of the synapse, we review studies that implicate tSCs in neuromuscular diseases including spinal muscular atrophy, Miller–Fisher syndrome, and amyotrophic lateral sclerosis, among others. We also discuss the importance of these cells on degeneration and regeneration after nerve injury. Knowledge of tSC biology may improve our understanding of disease pathogenesis and help us identify new and innovative therapeutic strategies for the many patients who suffer from neuromuscular disorders and nerve injuries.
KW - Schwann cells
KW - glia
KW - neuromuscular junction
UR - http://www.scopus.com/inward/record.url?scp=85043585844&partnerID=8YFLogxK
U2 - 10.1002/jnr.24231
DO - 10.1002/jnr.24231
M3 - Review article
C2 - 29536564
AN - SCOPUS:85043585844
SN - 0360-4012
VL - 96
SP - 1125
EP - 1135
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 7
ER -