Clinical Practice Recommendations for Hematopoietic Cell Transplantation and Cellular Therapies in Follicular Lymphoma: A Collaborative Effort on Behalf of the American Society for Transplantation and Cellular Therapy and the European Society for Blood and Marrow Transplantation

Madiha Iqbal, Ambuj Kumar, Peter Dreger, Julio Chavez, Craig S. Sauter, Anna M. Sureda, Veronika Bachanova, Richard T. Maziarz, Martin Dreyling, Sonali M. Smith, Caron Jacobson, Bertram Glass, Carla Casulo, Olalekan O. Oluwole, Silvia Montoto, Ranjana Advani, Jonathon Cohen, Gilles Salles, Nada Hamad, John KuruvillaBrad S. Kahl, Mazyar Shadman, Abraham S. Kanate, Lihua Elizabeth Budde, Manali Kamdar, Christopher Flowers, Mehdi Hamadani, Mohamed A. Kharfan-Dabaja

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL), accounting for nearly one-third of all NHL. The therapeutic landscape for patients with FL has significantly expanded over the past decade, but the disease continues to be considered incurable. Hematopoietic cell transplantation (HCT) is potentially curative in some cases. Recently, the emergence of chimeric antigen receptor T-cell therapy (CAR-T) for patients with relapsed/refractory (R/R) FL has yielded impressive response rates and long-term remissions, but definitive statement on the curative potential of CAR-T is currently not possible due to limited patient numbers and relatively short follow up. A consensus on the contemporary role, optimal timing, and sequencing of HCT (autologous or allogeneic) and cellular therapies in FL is needed. As a result, the American Society of Transplantation and Cellular Therapy (ASTCT) Committee on Practice Guidelines endorsed this effort to formulate consensus recommendations to address this unmet need. The RAND-modified Delphi method was used to generate 15 consensus statements/recommendations. These clinical practice recommendations will help guide clinicians managing patients with FL. Of note, the use of bispecific antibodies in R/R FL was not in the scope of this project.

Original languageEnglish
Pages (from-to)832-843
Number of pages12
JournalTransplantation and Cellular Therapy
Volume30
Issue number9
DOIs
StatePublished - Sep 2024

Keywords

  • allogeneic transplant
  • autologous transplantation
  • CAR T-cell therapy
  • cellular therapy
  • consensus
  • Follicular lymphoma

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