Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

Andrew G. Horti; Dean F. Wong

doi:10.1016/j.cpet.2009.04.014

Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

Andrew G. Horti, Dean F. Wong

Precision Radio-Theranostics Translational Laboratories (PRT2L)

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Cerebral nicotinic acetylcholine receptors (nAChR) are linked to various brain functions and disorders. There is a critical necessity for PET imaging of nAChR to study the role of the nicotinic system in the central nervous system. Currently, only two PET radioligands (2-[¹⁸F]FA and 6-[¹⁸F]FA) for the nAChR imaging are available, but they exhibit substantial drawbacks in imaging quality and potential for quantification. This article summarizes recent progress in the PET imaging of nAChR human subjects and surveys the studies of several research groups whose aim is the development of nAChR PET radioligands with improved imaging properties.

Original language	English
Pages (from-to)	89-100
Number of pages	12
Journal	PET Clinics
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.cpet.2009.04.014
State	Published - Jan 2009

Keywords

Nicotine
PET
Positron emission tomography
Radioligands
nAChR

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10.1016/j.cpet.2009.04.014

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title = "Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors",

abstract = "Cerebral nicotinic acetylcholine receptors (nAChR) are linked to various brain functions and disorders. There is a critical necessity for PET imaging of nAChR to study the role of the nicotinic system in the central nervous system. Currently, only two PET radioligands (2-[18F]FA and 6-[18F]FA) for the nAChR imaging are available, but they exhibit substantial drawbacks in imaging quality and potential for quantification. This article summarizes recent progress in the PET imaging of nAChR human subjects and surveys the studies of several research groups whose aim is the development of nAChR PET radioligands with improved imaging properties.",

keywords = "Nicotine, PET, Positron emission tomography, Radioligands, nAChR",

author = "Horti, {Andrew G.} and Wong, {Dean F.}",

note = "Funding Information: This research was supported by National Institutes of Health Grants MH079017 and DA020777 and by the Division of Nuclear Medicine of the Johns Hopkins School of Medicine. ",

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AU - Wong, Dean F.

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AB - Cerebral nicotinic acetylcholine receptors (nAChR) are linked to various brain functions and disorders. There is a critical necessity for PET imaging of nAChR to study the role of the nicotinic system in the central nervous system. Currently, only two PET radioligands (2-[18F]FA and 6-[18F]FA) for the nAChR imaging are available, but they exhibit substantial drawbacks in imaging quality and potential for quantification. This article summarizes recent progress in the PET imaging of nAChR human subjects and surveys the studies of several research groups whose aim is the development of nAChR PET radioligands with improved imaging properties.

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KW - PET

KW - Positron emission tomography

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JO - PET Clinics

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Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

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Keywords

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