Rendimiento clínico de biopsia de mapeo guiada por plantilla transperineal para la toma de decisiones terapéuticas en el cáncer de próstata de bajo riesgo

Translated title of the contribution: Clinical performance of transperineal template guided mapping biopsy for therapeutic decision making in low risk prostate cancer

Y. Ahallal, R. Sanchez-Salas, A. Sivaraman, E. Barret, F. P. Secin, P. Validire, F. Rozet, M. Galiano, X. Cathelineau

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objectives To evaluate the role of Transperineal Template guided Mapping Biopsy (TTMB) in determining the management strategy in patients with low risk prostate cancer (PCa). Methods We retroscpectively evaluated 169 patients who underwent TTMB at our institution from February 2008 to June 2011. Ninety eight of them harbored indolent PCa defined as: Prostate Specific Antigen < 10 ng/ml, Gleason score 6 or less, clinical stage T2a or less, unilateral disease and a maximum of one third positive cores at first biopsy and < 50% of the core involved. TTMB results were analyzed for Gleason score upgrading and upstaging as compared to initial TransRectal UltraSound (TRUS) biopsies and its influence on the change in the treatment decisions. Results TTMB detected cancer in 64 (65%) patients. The upgrade, upstage and both were noted in 33% (n = 21), 12% (n = 8) and 7% (n = 5) respectively of the detected cancers. The disease characteristics was similar to initial TRUS in 30 (48%) patients and TTMB was negative in 34 (35%) patients. Prostate volume was significantly smaller in patients with upgrade and/or upstage noted at TTMB (45.4 vs 37.9; P = .03). TTMB results influenced 73.5% of upgraded and/or upstaged patients to receive radical treatment while 81% of the patients with unmodified stage and/or grade continued active surveillance or focal therapy. Conclusions In patients with low risk PCa diagnosed by TRUS, subsequent TTMB demonstrated cancer upgrade and/or upstage in about one-third of the patients and resulted in eventual change in treatment decision.

Translated title of the contributionClinical performance of transperineal template guided mapping biopsy for therapeutic decision making in low risk prostate cancer
Original languageSpanish
Pages (from-to)615-620
Number of pages6
JournalActas Urologicas Espanolas
Volume40
Issue number10
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Keywords

  • Active surveillance
  • Prostate biopsy
  • Prostate cancer
  • Template guided biopsy
  • Transperineal biopsy

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