Clinical Neurogenetics: Recent Advances in the Genetics of Epilepsy

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Epilepsy represents a diverse group of disorders with primary and secondary genetic etiologies, as well as non-genetic causes. As more causative genes are identified, genetic testing is becoming increasingly important in the evaluation and management of epilepsy. This article outlines the clinical approach to epilepsy patients, with emphasis on genetic testing. Specific targeted tests are available for numerous individual genetic causes of epilepsy. Broader screening tests, such as chromosome microarray analysis and whole exome sequencing, have also been developed. As a standardized protocol for genetic testing has not been established, individualized diagnostic approaches to epilepsy patients should be used.

Original languageEnglish
Pages (from-to)891-913
Number of pages23
JournalNeurologic Clinics
Volume31
Issue number4
DOIs
StatePublished - Nov 1 2013

Keywords

  • Epilepsy
  • Genetics
  • Seizure

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