TY - JOUR
T1 - Clinical Investigation of Duchenne Muscular Dystrophy
T2 - Interesting Results in a Trial of Prednisone
AU - Brooke, Michael H.
AU - Fenichel, Gerald M.
AU - Griggs, Robert C.
AU - Mendell, Jerry R.
AU - Moxley, Richard T.
AU - Miller, J. Philip
AU - Kaiser, Kenneth K.
AU - Florence, Julaine M.
AU - Pandya, Shree
AU - Signore, Linda
AU - King, Wendy
AU - Robison, Jenny
AU - Head, Richard A.
AU - Province, Michael A.
AU - Seyfried, Warren
AU - Mandel, Stephen
PY - 1987/8
Y1 - 1987/8
N2 - We investigated the effect of highdose prednisone therapy in 33 boys with Duchenne muscular dystrophy. The drug was given daily in doses of 1.5 mg/kg of body weight (to a maximum of 80 mg) for six months. Muscle strength, joint contractures, timed functional tests, functional ability, and pulmonary function were measured at the beginning and end of the treatment period. The trial was designed using natural history controls, and the power of the study was 0.80 to detect a slowing of 50% in the rate of progression. During the period of the trial, muscle strength, functional grades, timed functional tests, and pulmonary function improved. Contractures followed the expected natural history of the illness.
AB - We investigated the effect of highdose prednisone therapy in 33 boys with Duchenne muscular dystrophy. The drug was given daily in doses of 1.5 mg/kg of body weight (to a maximum of 80 mg) for six months. Muscle strength, joint contractures, timed functional tests, functional ability, and pulmonary function were measured at the beginning and end of the treatment period. The trial was designed using natural history controls, and the power of the study was 0.80 to detect a slowing of 50% in the rate of progression. During the period of the trial, muscle strength, functional grades, timed functional tests, and pulmonary function improved. Contractures followed the expected natural history of the illness.
UR - http://www.scopus.com/inward/record.url?scp=0023389864&partnerID=8YFLogxK
U2 - 10.1001/archneur.1987.00520200016010
DO - 10.1001/archneur.1987.00520200016010
M3 - Article
C2 - 3632393
AN - SCOPUS:0023389864
SN - 0003-9942
VL - 44
SP - 812
EP - 817
JO - Archives of neurology
JF - Archives of neurology
IS - 8
ER -