Clinical investigation in Duchenne muscular dystrophy: Penicillamine and vitamin E

Gerald M. Fenichel; Michael H. Brooke; Robert C. Griggs; Jerry R. Mendell; J. Phillip Miller; Richard T. Moxley; Jane H. Park; Michael A. Provine; Julaine Florence; Kenneth K. Kaiser; Wendy M. King; Shree Pandya; Jenny Robison; Linda Signore

doi:10.1002/mus.880111110

Clinical investigation in Duchenne muscular dystrophy: Penicillamine and vitamin E

Gerald M. Fenichel, Michael H. Brooke, Robert C. Griggs, Jerry R. Mendell, J. Phillip Miller, Richard T. Moxley, Jane H. Park, Michael A. Provine, Julaine Florence, Kenneth K. Kaiser, Wendy M. King, Shree Pandya, Jenny Robison, Linda Signore

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Abstract

A double‐blind controlled trial of penicillamine and vitamin E against placebo was conducted in 106 boys with Duchenne muscular dystrophy. Nine dropped out of the study after being randomized. Patients were evaluated using an established protocol that measures muscle strength, joint contractures, functional grade, and pulmonary function. The trial lasted for 18 months. The power of the study to detect a 75% slowing of the disease was 0.95 at a P < 0.05. No therapeutic effect was observed in the patients taking penicillamine and vitamin E as compared with those taking placebo.

Original language	English
Pages (from-to)	1164-1168
Number of pages	5
Journal	Muscle & Nerve
Volume	11
Issue number	11
DOIs	https://doi.org/10.1002/mus.880111110
State	Published - Nov 1988

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title = "Clinical investigation in Duchenne muscular dystrophy: Penicillamine and vitamin E",

abstract = "A double‐blind controlled trial of penicillamine and vitamin E against placebo was conducted in 106 boys with Duchenne muscular dystrophy. Nine dropped out of the study after being randomized. Patients were evaluated using an established protocol that measures muscle strength, joint contractures, functional grade, and pulmonary function. The trial lasted for 18 months. The power of the study to detect a 75% slowing of the disease was 0.95 at a P < 0.05. No therapeutic effect was observed in the patients taking penicillamine and vitamin E as compared with those taking placebo.",

author = "Fenichel, {Gerald M.} and Brooke, {Michael H.} and Griggs, {Robert C.} and Mendell, {Jerry R.} and Miller, {J. Phillip} and Moxley, {Richard T.} and Park, {Jane H.} and Provine, {Michael A.} and Julaine Florence and Kaiser, {Kenneth K.} and King, {Wendy M.} and Shree Pandya and Jenny Robison and Linda Signore",

year = "1988",

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doi = "10.1002/mus.880111110",

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AU - Fenichel, Gerald M.

AU - Brooke, Michael H.

AU - Griggs, Robert C.

AU - Mendell, Jerry R.

AU - Miller, J. Phillip

AU - Moxley, Richard T.

AU - Park, Jane H.

AU - Provine, Michael A.

AU - Florence, Julaine

AU - Kaiser, Kenneth K.

AU - King, Wendy M.

AU - Pandya, Shree

AU - Robison, Jenny

AU - Signore, Linda

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Clinical investigation in Duchenne muscular dystrophy: Penicillamine and vitamin E

Abstract

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