Clinical implications of neoepitope landscapes for adult and pediatric cancers

Yang Yang Feng; Obi L. Griffith; Malachi Griffith

doi:10.1186/s13073-017-0470-9

Clinical implications of neoepitope landscapes for adult and pediatric cancers

Yang Yang Feng, Obi L. Griffith, Malachi Griffith

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers. See related research article 10.1186/s13073-017-0468-3

Original language	English
Article number	77
Journal	Genome medicine
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s13073-017-0470-9
State	Published - Aug 31 2017

Keywords

Exome sequencing
Immunotherapy
Neoepitope
Personalized cancer vaccine
RNA sequencing
Whole-genome sequencing

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10.1186/s13073-017-0470-9

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abstract = "Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers. See related research article 10.1186/s13073-017-0468-3",

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KW - Whole-genome sequencing

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Clinical implications of neoepitope landscapes for adult and pediatric cancers

Abstract

Keywords

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