Clinical Impact of Revised Cefepime Breakpoint in Patients with Enterobacteriaceae Bacteremia

Kap Sum Foong; Abigail L. Carlson; Satish Munigala; Carey Ann D. Burnham; David K. Warren

doi:10.1093/ofid/ofz341

Clinical Impact of Revised Cefepime Breakpoint in Patients with Enterobacteriaceae Bacteremia

Kap Sum Foong, Abigail L. Carlson, Satish Munigala, Carey Ann D. Burnham, David K. Warren

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9 Scopus citations

Abstract

The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbiological failure, regardless of isolates being susceptible or cefepime-susceptible dose-dependent by current criteria.

Original language	English
Article number	ofz341
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofz341
State	Published - Aug 1 2019

Keywords

CLSI
Enterobacteriaceae
bacteremia
cefepime
cefepime-susceptible dose-dependent
susceptibility

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10.1093/ofid/ofz341

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title = "Clinical Impact of Revised Cefepime Breakpoint in Patients with Enterobacteriaceae Bacteremia",

abstract = "The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbiological failure, regardless of isolates being susceptible or cefepime-susceptible dose-dependent by current criteria.",

keywords = "CLSI, Enterobacteriaceae, bacteremia, cefepime, cefepime-susceptible dose-dependent, susceptibility",

author = "Foong, {Kap Sum} and Carlson, {Abigail L.} and Satish Munigala and Burnham, {Carey Ann D.} and Warren, {David K.}",

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AU - Burnham, Carey Ann D.

AU - Warren, David K.

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AB - The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbiological failure, regardless of isolates being susceptible or cefepime-susceptible dose-dependent by current criteria.

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KW - Enterobacteriaceae

KW - bacteremia

KW - cefepime

KW - cefepime-susceptible dose-dependent

KW - susceptibility

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Clinical Impact of Revised Cefepime Breakpoint in Patients with Enterobacteriaceae Bacteremia

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Keywords

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