TY - JOUR
T1 - Clinical features and comorbidity of mood fluctuations in Parkinson's disease
AU - Racette, Brad A.
AU - Hartlein, Johanna M.
AU - Hershey, Tamara
AU - Mink, Jonathan W.
AU - Perlmutter, Joel S.
AU - Black, Kevin J.
PY - 2002
Y1 - 2002
N2 - Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor "on" or "off" states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.
AB - Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor "on" or "off" states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.
UR - http://www.scopus.com/inward/record.url?scp=0036753611&partnerID=8YFLogxK
U2 - 10.1176/jnp.14.4.438
DO - 10.1176/jnp.14.4.438
M3 - Article
C2 - 12426412
AN - SCOPUS:0036753611
SN - 0895-0172
VL - 14
SP - 438
EP - 442
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 4
ER -