Clinical complications of tendon tissue mechanics due to collagen cross-linking in diabetes

Jennifer A. Zellers; Jeremy D. Eekhoff; Simon Tang; Mary K. Hastings; Spencer P. Lake

doi:10.1016/B978-0-12-821070-3.00009-X

Clinical complications of tendon tissue mechanics due to collagen cross-linking in diabetes

Jennifer A. Zellers, Jeremy D. Eekhoff, Simon Tang, Mary K. Hastings, Spencer P. Lake

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Diabetes is characterized by a hyperglycemic environment, which promotes accumulation of advanced glycation end products (AGEs). In tendon tissue, AGEs build-up results in alterations in collagen structure and binding along with changes in the noncollagenous components of tendon tissue. These changes are believed to result in stiffening of the tendon tissue; however, experimental data suggest that the impact of AGEs to tendon mechanics may be more nuanced. For example, alterations in tendon biochemistry and sliding mechanics may lead to impaired homeostasis and consequent degenerative changes that could lead to decreased stiffness. Additional investigation translating the effect of AGEs in tendon tissue to specific tendon-related clinical syndromes would be beneficial to identify specific treatment targets and better tailor medical and rehabilitative intervention for individuals with diabetes.

Original language	English
Title of host publication	The Science, Etiology and Mechanobiology of Diabetes and its Complications
Publisher	Elsevier
Pages	201-226
Number of pages	26
ISBN (Electronic)	9780128210703
DOIs	https://doi.org/10.1016/B978-0-12-821070-3.00009-X
State	Published - Jan 1 2021

Keywords

Achilles
Collagen
Cross-linking
Diabetes
Glycation
Rotator cuff
Trigger finger

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10.1016/B978-0-12-821070-3.00009-X

Cite this

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abstract = "Diabetes is characterized by a hyperglycemic environment, which promotes accumulation of advanced glycation end products (AGEs). In tendon tissue, AGEs build-up results in alterations in collagen structure and binding along with changes in the noncollagenous components of tendon tissue. These changes are believed to result in stiffening of the tendon tissue; however, experimental data suggest that the impact of AGEs to tendon mechanics may be more nuanced. For example, alterations in tendon biochemistry and sliding mechanics may lead to impaired homeostasis and consequent degenerative changes that could lead to decreased stiffness. Additional investigation translating the effect of AGEs in tendon tissue to specific tendon-related clinical syndromes would be beneficial to identify specific treatment targets and better tailor medical and rehabilitative intervention for individuals with diabetes.",

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AU - Eekhoff, Jeremy D.

AU - Tang, Simon

AU - Hastings, Mary K.

AU - Lake, Spencer P.

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AB - Diabetes is characterized by a hyperglycemic environment, which promotes accumulation of advanced glycation end products (AGEs). In tendon tissue, AGEs build-up results in alterations in collagen structure and binding along with changes in the noncollagenous components of tendon tissue. These changes are believed to result in stiffening of the tendon tissue; however, experimental data suggest that the impact of AGEs to tendon mechanics may be more nuanced. For example, alterations in tendon biochemistry and sliding mechanics may lead to impaired homeostasis and consequent degenerative changes that could lead to decreased stiffness. Additional investigation translating the effect of AGEs in tendon tissue to specific tendon-related clinical syndromes would be beneficial to identify specific treatment targets and better tailor medical and rehabilitative intervention for individuals with diabetes.

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KW - Cross-linking

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KW - Glycation

KW - Rotator cuff

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Clinical complications of tendon tissue mechanics due to collagen cross-linking in diabetes

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Keywords

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