Clinical Characteristics of Primary Vitreoretinal Lymphoma in an Indian Population

Sarakshi Mahajan, Raje Nijhawan, Aravind Rajwanshi, Samendra Karkhur, Samyak Mulkutar, Mohit Dogra, Vivek Lal, Vishali Gupta, Amod Gupta

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11 Scopus citations


Purpose: Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population.Methods: Retrospective chart reviews of 12 patients with a diagnosis of PVRL.Results: The study included 6 men and 6 women, with a mean age of 55.66 ± 8.76 years. All had bilateral disease. The clinical signs included anterior uveitis (12 eyes; 50.0%); vitritis (18 eyes; 75%); vitreous clumps (16 eyes; 66.6%); subretinal deposits (11 eyes; 45.8%); retinal vasculitis (6 eyes; 25%); and optic disc swelling (2 eyes; 8.3%). The most commonly mistaken diagnosis was intraocular tuberculosis. The intraocular lesions responded to multiple intravitreal methotrexate injections.Conclusions: PVRL in India was likely to be mistaken for an infectious variety of uveitis. A high index of suspicion and thorough clinical examination is necessary to make the diagnosis.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalOcular Immunology and Inflammation
Issue number5
StatePublished - Sep 3 2017


  • intravitreal methotrexate
  • primary CNS lymphoma
  • Primary vitreoretinal lymphoma
  • subretinal deposits
  • uveitis


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