TY - JOUR
T1 - Clinical characteristics of eyes demonstrating atypical patterns in scanning laser polarimetry
AU - Orlev, A.
AU - Horani, A.
AU - Rapson, Y.
AU - Cohen, M. J.
AU - Blumenthal, E. Z.
PY - 2008/11
Y1 - 2008/11
N2 - Purpose To characterize which clinical features are associated with the occurrence of atypical birefringence patterns (ABP) occasionally seen with scanning laser polarimetry (SLP). Methods Sixty-one subjects, including glaucoma patients, glaucoma suspects, and normal subjects, underwent a full clinical examination, standard visual field (VF) test, and a GDx-VCC SLP examination. One eye was selected from each patient. The magnitude of ABP was determined in two independent ways: using a support vector machine analysis (typical scan score (TSS)) and by a masked experienced observer. We assessed whether the magnitude of ABP was correlated with age, gender, the refractive state of the eye, corneal polarization axis and magnitude, GDx global parameters (TSNIT and NFI), and the VF status, as evident from glaucoma hemifield test (GHT), mean deviation (MD), and the pattern standard deviation (PSD). Results Of the 61 study eyes, 27 (44%) showed an ABP, based on a TSS cutoff (82.5). A very high correlation was found between the TSS score and the masked experienced observer score (r 2 0.80; P0.001). The following clinical parameters were found, on bivariate analysis, to be significantly correlated with the presence of an ABP: age (r 2 0.086; P0.02); corneal polarization magnitude (r 2 0.069; P0.04); TSNIT (r 2 0.16; P0.001). Conclusion The presence and magnitude of ABP did not seem to be closely correlated with most clinical parameters. A low, but statistically significant, correlation was found for age and corneal polarization magnitude (r 2 0.086 and 0.069, respectively). A low-medium correlation was found for TSNIT (r 2 0.16); however, we speculate that this might represent a confounding effect, rather than an underlying association. We conclude that none of the clinical parameters investigated in this study appears to be strongly correlated with the presence of an ABP on SLP scans performed using the commercially available GDx-VCC.
AB - Purpose To characterize which clinical features are associated with the occurrence of atypical birefringence patterns (ABP) occasionally seen with scanning laser polarimetry (SLP). Methods Sixty-one subjects, including glaucoma patients, glaucoma suspects, and normal subjects, underwent a full clinical examination, standard visual field (VF) test, and a GDx-VCC SLP examination. One eye was selected from each patient. The magnitude of ABP was determined in two independent ways: using a support vector machine analysis (typical scan score (TSS)) and by a masked experienced observer. We assessed whether the magnitude of ABP was correlated with age, gender, the refractive state of the eye, corneal polarization axis and magnitude, GDx global parameters (TSNIT and NFI), and the VF status, as evident from glaucoma hemifield test (GHT), mean deviation (MD), and the pattern standard deviation (PSD). Results Of the 61 study eyes, 27 (44%) showed an ABP, based on a TSS cutoff (82.5). A very high correlation was found between the TSS score and the masked experienced observer score (r 2 0.80; P0.001). The following clinical parameters were found, on bivariate analysis, to be significantly correlated with the presence of an ABP: age (r 2 0.086; P0.02); corneal polarization magnitude (r 2 0.069; P0.04); TSNIT (r 2 0.16; P0.001). Conclusion The presence and magnitude of ABP did not seem to be closely correlated with most clinical parameters. A low, but statistically significant, correlation was found for age and corneal polarization magnitude (r 2 0.086 and 0.069, respectively). A low-medium correlation was found for TSNIT (r 2 0.16); however, we speculate that this might represent a confounding effect, rather than an underlying association. We conclude that none of the clinical parameters investigated in this study appears to be strongly correlated with the presence of an ABP on SLP scans performed using the commercially available GDx-VCC.
KW - Atypical birefringence pattern
KW - GDx-VCC
KW - Glaucoma diagnosis
KW - Glaucoma imaging
KW - Retinal nerve fiber layer
KW - Scanning laser polarimetry
UR - http://www.scopus.com/inward/record.url?scp=67649399551&partnerID=8YFLogxK
U2 - 10.1038/sj.eye.6702897
DO - 10.1038/sj.eye.6702897
M3 - Article
C2 - 17627289
AN - SCOPUS:67649399551
SN - 0950-222X
VL - 22
SP - 1378
EP - 1383
JO - Eye
JF - Eye
IS - 11
ER -