Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

doi:10.1016/j.jpeds.2022.07.033

Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	Journal of Pediatrics
Volume	250
DOIs	https://doi.org/10.1016/j.jpeds.2022.07.033
State	Published - Nov 2022

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10.1016/j.jpeds.2022.07.033

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title = "Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis",

abstract = "Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.",

author = "\{Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group\} and Glaser, \{Nicole S.\} and Quayle, \{Kimberly S.\} and McManemy, \{Julie K.\} and Nigrovic, \{Lise E.\} and Leah Tzimenatos and Stoner, \{Michael J.\} and Bennett, \{Jonathan E.\} and Trainor, \{Jennifer L.\} and Arleta Rewers and Schunk, \{Jeff E.\} and Myers, \{Sage R.\} and Kwok, \{Maria Y.\} and Brown, \{Kathleen M.\} and Simona Ghetti and Casper, \{T. Charles\} and Olsen, \{Cody S.\} and Nathan Kuppermann",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = nov,

doi = "10.1016/j.jpeds.2022.07.033",

language = "English",

volume = "250",

pages = "100--104",

journal = "Journal of Pediatrics",

issn = "0022-3476",

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T1 - Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

AU - Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

AU - Glaser, Nicole S.

AU - Quayle, Kimberly S.

AU - McManemy, Julie K.

AU - Nigrovic, Lise E.

AU - Tzimenatos, Leah

AU - Stoner, Michael J.

AU - Bennett, Jonathan E.

AU - Trainor, Jennifer L.

AU - Rewers, Arleta

AU - Schunk, Jeff E.

AU - Myers, Sage R.

AU - Kwok, Maria Y.

AU - Brown, Kathleen M.

AU - Ghetti, Simona

AU - Casper, T. Charles

AU - Olsen, Cody S.

AU - Kuppermann, Nathan

PY - 2022/11

Y1 - 2022/11

N2 - Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

AB - Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

UR - https://www.scopus.com/pages/publications/85136655283

U2 - 10.1016/j.jpeds.2022.07.033

DO - 10.1016/j.jpeds.2022.07.033

M3 - Article

C2 - 35944716

AN - SCOPUS:85136655283

SN - 0022-3476

VL - 250

SP - 100

EP - 104

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

Abstract

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