Clinical Characteristics, Complications, and Treatment Practices in Patients With RHD: 6-Year Results From HP-RHD Registry

Prakash Chand Negi, Kunal Mahajan, Vivek Rana, Sachin Sondhi, Nitin Mahajan, Sanjay Rathour, Ritesh Verma, Ashish Dhiman, Munish Dev, Shivani Rao, Sanjeev Asotra, Rajeev Bhardwaj, Neeraj Ganju, Arvind Kandoria, Rajeev Merwaha, Rajesh Sharma, Nirmal Kolte, Ravi Kumar V, Prince Kumar Paul, Davinder Pal Singh

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Abstract

Background: Despite the high prevalence of rheumatic heart disease (RHD) in developing countries such as India, data on characteristics, complications, and treatment practices are lacking. The HP-RHD (Himachal Pradesh Rheumatic Heart Disease) registry aimed at reporting these parameters in patients with RHD from a northern state of India. Methods: A total of 2,005 consecutive patients of RHD were enrolled over a period of 6 years (2011 to 2016) in the present study. The clinical characteristics, complications, and treatment practices were systematically recorded. Results: The mean age for patients with RHD was 40.3 ± 14.3 (range 5 to 83 years). RHD predominantly affected females (72.3%) and population from rural background (92%). Multivalvular involvement was frequent (43.2%), mitral valve was the commonest affected valve (83.3%). The majority of the patients had moderate-to-severe valvular dysfunction (69.3%). Mitral and tricuspid valve involvement was more frequent in female subjects compared with more frequent aortic valve involvement in male subjects (p < 0.001). The major adverse cardiovascular events were recorded in 23.4% patients at the time of registry and comprised mainly advanced heart failure (15.6%), peripheral embolism (4.1%), and stroke (3.9%). The independent risk determinants of major adverse cardiovascular events (were advanced age (odds ratio [OR]: 1.01; 95% confidence interval [CI]: 1.00–1.02), severe mitral stenosis (OR: 1.73; 95% CI: 1.34–2.20), severe tricuspid regurgitation (OR: 2.11; 95% CI: 1.48–3.02), presence of pulmonary artery hypertension (OR: 1.33; 95% CI: 1.04–1.69), and atrial fibrillation (OR: 1.64; 95% CI: 1.28–2.11). Evidence-based use of oral anticoagulant therapy was documented in 77.7% of high-risk patients. Only 28.5% of study population was receiving secondary prophylaxis. Conclusions: Complications in patients with RHD increase with age and worsening valvular dysfunction. Programs focused on early detection and evidence-based management will assist in improving outcomes.

Original languageEnglish
Pages (from-to)267-274.e2
JournalGlobal Heart
Volume13
Issue number4
DOIs
StatePublished - Dec 2018

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    Negi, P. C., Mahajan, K., Rana, V., Sondhi, S., Mahajan, N., Rathour, S., Verma, R., Dhiman, A., Dev, M., Rao, S., Asotra, S., Bhardwaj, R., Ganju, N., Kandoria, A., Merwaha, R., Sharma, R., Kolte, N., Kumar V, R., Paul, P. K., & Singh, D. P. (2018). Clinical Characteristics, Complications, and Treatment Practices in Patients With RHD: 6-Year Results From HP-RHD Registry. Global Heart, 13(4), 267-274.e2. https://doi.org/10.1016/j.gheart.2018.06.001