TY - JOUR
T1 - Clinical cerenkov luminescence imaging of 18F-FDG
AU - Thorek, Daniel L.J.
AU - Riedl, Christopher C.
AU - Grimm, Jan
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.
AB - The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.
KW - Cerenkov luminescence imaging
KW - Clinical
KW - PET/CT
UR - http://www.scopus.com/inward/record.url?scp=84894767436&partnerID=8YFLogxK
U2 - 10.2967/jnumed.113.127266
DO - 10.2967/jnumed.113.127266
M3 - Article
C2 - 24078721
AN - SCOPUS:84894767436
SN - 0161-5505
VL - 55
SP - 95
EP - 98
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 1
ER -