Clinical cerenkov luminescence imaging of 18F-FDG

Daniel L.J. Thorek, Christopher C. Riedl, Jan Grimm

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalJournal of Nuclear Medicine
Volume55
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cerenkov luminescence imaging
  • Clinical
  • PET/CT

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