Clinical attribute network for chronic lymphocytic leukemia

Abhisek Kundu, Hatice Gulcin Ozer, Tara Borlawsky, Kristin C. Circle, Kun Huang, Philip Payne

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In this paper, we present a study on the relationships between Chronic Lymphocytic Leukemia (CLL) related clinical attributes using network visualization and analysis techniques. This work is the first step of our long-term project to identify novel biomarkers for CLL, working in coordination with the NCI-funded CLL Research Consortium (cll.ucsd.edu). By computing Spearman correlation coefficients for 125 clinical attributes, we established an attribute network for CLL. Using network visualization techniques we identified a core network with peripheral nodes around it. An important observation is that many cytogenetic attributes are in the core network, indicating the connection between karyotypes (e.g., abnormality in Chromosome 17) and other clinical attributes. Since these karyotypes are linked to CLL etiology in many ways, the corresponding clinical attributes may be further selected and tested as markers for disease screening. The correlation analysis results are also consistent with previous studies using a knowledge engineering based approach for establishing relationships between such attributes.

Original languageEnglish
Title of host publication2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009
Pages279-282
Number of pages4
DOIs
StatePublished - Dec 1 2009
Externally publishedYes
Event2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009 - Washington, D.C., United States
Duration: Nov 1 2009Nov 4 2009

Publication series

Name2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009

Conference

Conference2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009
CountryUnited States
CityWashington, D.C.
Period11/1/0911/4/09

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    Kundu, A., Ozer, H. G., Borlawsky, T., Circle, K. C., Huang, K., & Payne, P. (2009). Clinical attribute network for chronic lymphocytic leukemia. In 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009 (pp. 279-282). [5341786] (2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009). https://doi.org/10.1109/BIBM.2009.77