TY - GEN
T1 - Clinical assessment and mathematical modeling of the accuracy of Continuous Glucose Sensors (CGS)
AU - Kovatchev, Boris P.
AU - King, Christopher
AU - Breton, Marc
AU - Anderson, Stacey
PY - 2006
Y1 - 2006
N2 - In the treatment of diabetes, CGS calibration, time lag, and random errors influence the clinical glucose control decisions based on CGS output. These inaccuracies are determined by three main factors: quality of calibration, physiology, and sensor engineering. Simulated re-calibration and a diffusion model of blood-to-interstitial glucose transport allow the separation of these sources of inaccuracy. The methods are illustrated by data for 39 subjects with Type 1 diabetes collected during hyperinsulinemic euglycemic/hypoglycemic clamp by Minimed CGMS™ (Medtronic, Northridge, CA). The continuous glucose error-grid analysis (CG-EGA) was used to evaluate sensor inaccuracy from a clinical point of view.
AB - In the treatment of diabetes, CGS calibration, time lag, and random errors influence the clinical glucose control decisions based on CGS output. These inaccuracies are determined by three main factors: quality of calibration, physiology, and sensor engineering. Simulated re-calibration and a diffusion model of blood-to-interstitial glucose transport allow the separation of these sources of inaccuracy. The methods are illustrated by data for 39 subjects with Type 1 diabetes collected during hyperinsulinemic euglycemic/hypoglycemic clamp by Minimed CGMS™ (Medtronic, Northridge, CA). The continuous glucose error-grid analysis (CG-EGA) was used to evaluate sensor inaccuracy from a clinical point of view.
UR - http://www.scopus.com/inward/record.url?scp=34047187106&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.260114
DO - 10.1109/IEMBS.2006.260114
M3 - Conference contribution
C2 - 17945569
AN - SCOPUS:34047187106
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 71
EP - 74
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -