Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Trung D. Tran, Shelton D. Caruthers, Michael Hughes, John N. Marsh, Tillmann Cyrus, Patrick M. Winter, Anne M. Neubauer, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.

Original languageEnglish
Pages (from-to)515-526
Number of pages12
JournalInternational Journal of Nanomedicine
Volume2
Issue number4
StatePublished - 2007

Keywords

  • Magnetic resonance imaging
  • Molecular imaging
  • Nanoparticles
  • Perfluorocarbon
  • Ultrasound

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