Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Trung D. Tran; Shelton D. Caruthers; Michael Hughes; John N. Marsh; Tillmann Cyrus; Patrick M. Winter; Anne M. Neubauer; Samuel A. Wickline; Gregory M. Lanza

Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Trung D. Tran, Shelton D. Caruthers, Michael Hughes, John N. Marsh, Tillmann Cyrus, Patrick M. Winter, Anne M. Neubauer, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.

Original language	English
Pages (from-to)	515-526
Number of pages	12
Journal	International Journal of Nanomedicine
Volume	2
Issue number	4
State	Published - 2007

Keywords

Magnetic resonance imaging
Molecular imaging
Nanoparticles
Perfluorocarbon
Ultrasound

Cite this

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title = "Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics",

abstract = "Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.",

keywords = "Magnetic resonance imaging, Molecular imaging, Nanoparticles, Perfluorocarbon, Ultrasound",

author = "Tran, {Trung D.} and Caruthers, {Shelton D.} and Michael Hughes and Marsh, {John N.} and Tillmann Cyrus and Winter, {Patrick M.} and Neubauer, {Anne M.} and Wickline, {Samuel A.} and Lanza, {Gregory M.}",

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T1 - Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

AU - Tran, Trung D.

AU - Caruthers, Shelton D.

AU - Hughes, Michael

AU - Marsh, John N.

AU - Cyrus, Tillmann

AU - Winter, Patrick M.

AU - Neubauer, Anne M.

AU - Wickline, Samuel A.

AU - Lanza, Gregory M.

PY - 2007

Y1 - 2007

N2 - Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.

AB - Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.

KW - Magnetic resonance imaging

KW - Molecular imaging

KW - Nanoparticles

KW - Perfluorocarbon

KW - Ultrasound

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M3 - Review article

C2 - 18203420

AN - SCOPUS:42549101166

SN - 1176-9114

VL - 2

SP - 515

EP - 526

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

IS - 4

ER -

Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Abstract

Keywords

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