Clinical Applications for Diffusion Magnetic Resonance Imaging in Radiotherapy

Christina Tsien, Yue Cao, Thomas Chenevert

    Research output: Contribution to journalReview articlepeer-review

    72 Scopus citations


    In this article, we review the clinical applications of diffusion magnetic resonance imaging (MRI) in the radiotherapy treatment of several key clinical sites, including those of the central nervous system, the head and neck, the prostate, and the cervix. Diffusion-weighted MRI (DWI) is an imaging technique that is rapidly gaining widespread acceptance owing to its ease and wide availability. DWI measures the mobility of water within tissue at the cellular level without the need of any exogenous contrast agent. For radiotherapy treatment planning, DWI improves upon conventional imaging techniques, by better characterization of tumor tissue properties required for tumor grading, diagnosis, and target volume delineation. Because DWI is also a sensitive marker for alterations in tumor cellularity, it has potential clinical applications in the early assessment of treatment response following radiation therapy.

    Original languageEnglish
    Pages (from-to)218-226
    Number of pages9
    JournalSeminars in Radiation Oncology
    Issue number3
    StatePublished - Jul 2014


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