Clinical application of heart rate variability after acute myocardial infarction

Heikki V. Huikuri, Phyllis K. Stein

Research output: Contribution to journalShort surveypeer-review

70 Scopus citations


Heart rate (HR) variability has been extensively studied in patients surviving an acute myocardial infarction (AMI).The majority of studies have shown that patients with reduced or abnormal HR variability/turbulence have an increased risk of mortality within few years after an AMI. Various measures of HR dynamics, such as time-domain, spectral, and non-linear measures of HR variability, as well as HR turbulence, have been used in risk stratification of post-AMI patients. The prognostic power of various measures, except of those reflecting rapid R-R interval oscillations, has been almost identical, albeit some non-linear HR variability measures, such as short-term fractal scaling exponent, and HR turbulence, have provided somewhat better prognostic information than the others. Abnor- mal HR variability predicts both sudden and non-sudden cardiac death after AMI. Because of remodeling of the arrhythmia substrate after AMI, early measurement of HR variabil- ity to identify those at high risk should likely be repeated later in order to assess the risk of fatal arrhythmia events. Future randomized trials using HR variability/turbulence as one of the pre-defined inclusion criteria will show whether routine measurement of HR variability/turbulence will become a routine clinical tool for risk stratification of post-AMI patients.

Original languageEnglish
Article numberArticle 41
JournalFrontiers in Physiology
Volume3 FEB
StatePublished - 2012


  • Coronary artery disease
  • Mortality
  • Sudden cardiac death


Dive into the research topics of 'Clinical application of heart rate variability after acute myocardial infarction'. Together they form a unique fingerprint.

Cite this