Clinical Application of Bioresorbable, Synthetic, Electrospun Matrix in Wound Healing

Matthew MacEwan, Lily Jeng, Tamás Kovács, Emily Sallade

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Electrospun polymeric matrices have long been investigated as constructs for use in regenerative medicine, yet relatively few have been commercialized for human clinical use. In 2017, a novel electrospun matrix, composed of two synthetic biocompatible polymers, polyglactin 910 (PLGA 10:90) and polydioxanone (PDO) of varying pore and fiber sizes (i.e., hybrid-scale) was developed and cleared by the FDA for human clinical use. The present review aims to explain the mechanism of action and review the preclinical and clinical results to summarize the efficacy of the matrix across multiple use cases within the wound care setting, including an assessment of over 150 wounds of varying etiologies treated with the synthetic matrix. Clinical data demonstrated effective use of the synthetic hybrid-scale fiber matrix across a variety of wound etiologies, including diabetic foot and venous leg ulcers, pressure ulcers, burns, and surgical wounds. This review represents a comprehensive clinical demonstration of a synthetic, electrospun, hybrid-scale matrix and illustrates its value and versatility across multiple wound etiologies.

Original languageEnglish
Article number9
JournalBioengineering
Volume10
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • Restrata
  • electrospinning
  • extracellular matrix
  • soft tissue repair
  • wound healing

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