TY - JOUR
T1 - Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
AU - Gimble, Jeffrey M.
AU - Guilak, Farshid
AU - Bunnell, Bruce A.
N1 - Funding Information:
The authors wish to acknowledge Ms Laura Dallam for excellent administrative and editorial assistance, Pedro Carvalho for critically reading the manuscript, Kotaro Yoshimura, MD, for reading the manuscript and sharing unpublished clinical data, and the following agencies for funding: Pennington Biomedical Research Foundation (to JMG), NIH grants AR50245 and AR48852, the Duke Translational Medicine Institute (RR024128) (to FG), Louisiana Gene Therapy Research Consortium and Tulane University (to BAB).
PY - 2010
Y1 - 2010
N2 - Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.
AB - Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.
UR - http://www.scopus.com/inward/record.url?scp=79960259749&partnerID=8YFLogxK
U2 - 10.1186/scrt19
DO - 10.1186/scrt19
M3 - Article
C2 - 20587076
AN - SCOPUS:79960259749
SN - 1757-6512
VL - 1
JO - Stem Cell Research and Therapy
JF - Stem Cell Research and Therapy
IS - 2
M1 - 19
ER -