Clinical and laboratory features of neuropathies with serum IgM binding to TS-HDS

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Introduction: In this investigation we studied clinical and laboratory features of polyneuropathies in patients with serum IgM binding to the trisulfated disaccharide IdoA2S-GlcNS-6S (TS-HDS). Methods:: We retrospectively compared 58 patients with selective IgM binding to TS-HDS to 41 consecutive patients with polyneuropathies without TS-HDS binding. Results:: Patients with IgM vs. TS-HDS commonly had distal, sensory, axonal neuropathies. Weakness was associated with IgM M-proteins. Hand pain and serum IgM M-proteins were more common than in control neuropathy patients. TS-HDS antibody binding was often selectively κ class. Biopsies showed capillary pathology with thickened basal lamina and C5b9 complement deposition. IgM in sera with TS-HDS antibodies often bound to capillaries. Conclusions:: Serum IgM binding to TS-HDS is associated with painful, sensory > motor, polyneuropathies with an increased frequency of persistent hand discomfort, serum IgM M-proteins, and capillary pathology. Serum IgM binding to TS-HDS suggests a possible immune etiology underlying some otherwise idiopathic sensory polyneuropathies.

Original languageEnglish
Pages (from-to)866-872
Number of pages7
JournalMuscle and Nerve
Issue number6
StatePublished - Jun 2012


  • Heparin disaccharide
  • IgM antibody
  • M-protein
  • Neuropathic
  • Pain
  • Sensory neuropathy


Dive into the research topics of 'Clinical and laboratory features of neuropathies with serum IgM binding to TS-HDS'. Together they form a unique fingerprint.

Cite this