Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis

Jan L. Kramer; Martin J. Bell; Katherine DeSchryver; Richard J. Bower; Jessie L. Ternberg; Neil H. White

doi:10.1016/0002-9610(82)90140-4

Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis

Jan L. Kramer, Martin J. Bell, Katherine DeSchryver, Richard J. Bower, Jessie L. Ternberg, Neil H. White

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33 Scopus citations

Abstract

Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreas revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.

Original language	English
Pages (from-to)	116-119
Number of pages	4
Journal	The American Journal of Surgery
Volume	143
Issue number	1
DOIs	https://doi.org/10.1016/0002-9610(82)90140-4
State	Published - Jan 1982

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title = "Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis",

abstract = "Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreas revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.",

author = "Kramer, {Jan L.} and Bell, {Martin J.} and Katherine DeSchryver and Bower, {Richard J.} and Ternberg, {Jessie L.} and White, {Neil H.}",

note = "Funding Information: From the Departments of Surgery, Pathology and Pediatrics, Washington University School of Medicine and St. Louis Children{\textquoteright}s Hospital, St. Louis, Missouri. Supported in part by Grants AM 20579, RR 00036 and 2T326M07602-04 from the National Institutes of Health, Bethesda, Maryland.",

year = "1982",

month = jan,

doi = "10.1016/0002-9610(82)90140-4",

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T1 - Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis

AU - Kramer, Jan L.

AU - Bell, Martin J.

AU - DeSchryver, Katherine

AU - Bower, Richard J.

AU - Ternberg, Jessie L.

AU - White, Neil H.

N1 - Funding Information: From the Departments of Surgery, Pathology and Pediatrics, Washington University School of Medicine and St. Louis Children’s Hospital, St. Louis, Missouri. Supported in part by Grants AM 20579, RR 00036 and 2T326M07602-04 from the National Institutes of Health, Bethesda, Maryland.

PY - 1982/1

Y1 - 1982/1

N2 - Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreas revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.

AB - Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreas revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.

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VL - 143

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JO - The American Journal of Surgery

JF - The American Journal of Surgery

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Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis

Abstract

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