Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis

Jan L. Kramer, Martin J. Bell, Katherine DeSchryver, Richard J. Bower, Jessie L. Ternberg, Neil H. White

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreas revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalThe American Journal of Surgery
Issue number1
StatePublished - Jan 1982


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