Clin-STAR corner: Practice changing advances in cardiology

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Although cardiovascular disease is the leading cause of death and major disability in older adults, older patients have been consistently under-represented in most cardiovascular clinical trials. This article summarizes the results of four trials published from 2020 to 2022 with practice-changing implications directly applicable to the care of older adults. The key findings from these trials were that: (1) an initial conservative approach to managing selected patients with stable ischemic heart disease is reasonable, even in the setting of moderate or severe ischemia; (2) empagliflozin is effective in reducing heart failure hospitalizations in patients with heart failure and preserved ejection fraction, with or without diabetes; (3) an individually tailored physical rehabilitation program reduces deconditioning and functional decline in older patients hospitalized with heart failure; and (4) restricting dietary sodium intake to less than 1500 mg/day is unlikely to improve outcomes in most patients with heart failure.

Original languageEnglish
Pages (from-to)1021-1027
Number of pages7
JournalJournal of the American Geriatrics Society
Issue number4
StatePublished - Apr 2023


  • cardiology
  • heart failure
  • ischemic heart disease
  • rehabilitation
  • sodium-glucose cotransporter-2 (SGLT2) inhibitors


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