TY - JOUR
T1 - Clearing the dead
T2 - Apoptotic cell sensing, recognition, engulfment, and digestion
AU - Hochreiter-Hufford, Amelia
AU - Ravichandran, Kodi S.
PY - 2013/1
Y1 - 2013/1
N2 - Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably, even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. Recently, significant progress has been made in understanding the steps involved in prompt cell clearance in vivo. These include the sensing of corpses via "find me" signals, the recognition of corpses via "eat me" signals and their cognate receptors, the signaling pathways that regulate cytoskeletal rearrangement necessary for engulfment, and the responses of the phagocyte that keep cell clearance events "immunologically silent." This study focuses on our understanding of these steps.
AB - Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably, even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. Recently, significant progress has been made in understanding the steps involved in prompt cell clearance in vivo. These include the sensing of corpses via "find me" signals, the recognition of corpses via "eat me" signals and their cognate receptors, the signaling pathways that regulate cytoskeletal rearrangement necessary for engulfment, and the responses of the phagocyte that keep cell clearance events "immunologically silent." This study focuses on our understanding of these steps.
UR - http://www.scopus.com/inward/record.url?scp=84872027397&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a008748
DO - 10.1101/cshperspect.a008748
M3 - Article
C2 - 23284042
AN - SCOPUS:84872027397
VL - 5
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
SN - 1943-0264
IS - 1
ER -