Clearance of bacteria from cerebrospinal fluid to blood in experimental meningitis

W. Michael Scheld, Tae Sung Park, Ralph G. Dacey, H. Richard Winn, John A. Jane, Merle A. Sande

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The occurrence and importance of secondary bacteremia in the pathogenesis of and response to therapy in meningitis is uncertain. Streptococcus pneumoniae type III was injected into the cerebrospinal fluid of the cisterna magna in anesthetized curarized dogs, and sequential simultaneous samples were obtained from the superior sagittal sinus, cisterna magna, and peripheral blood. The results show that: bacteria are rapidly transported from the cerebrospinal fluid to blood but only after active multiplication within the cerebrospinal fluid, and entrance into the blood from the cerebrospinal fluid occurs before the height of the febrile response or cerebrospinal fluid pleocytosis.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalUnknown Journal
Issue number1
StatePublished - 1979


Dive into the research topics of 'Clearance of bacteria from cerebrospinal fluid to blood in experimental meningitis'. Together they form a unique fingerprint.

Cite this