Clear cell neoplasms of the endocrine system and thymus

M. R. Wick, J. H. Ritter, P. A. Humphrey, O. Nappi

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Clear cell tumors of the endocrine system and thymus are rare lesions with which surgical pathologists have only infrequent contact. As a result, these neoplasms may be misinterpreted and incorrectly classified. This review considers the histological, immunohistochemical, and ultrastructural features of clear cell pituitary adenomas, parathyroid tumors, pancreatic endocrine neoplasms, adrenocortical proliferations, and thymic malignancies. Emphasis is placed throughout on differential diagnosis with microscopically-similar lesions. Clear cell endocrine tumors and thymic lesions manifest a variety of potential lineages, including examples with epithelial, neural, germ cell, and lymphoid differentiation. Because of the wide differences in behavior and recommended treatment in this group, accuracy in diagnosis is essential.

Original languageEnglish
Pages (from-to)183-202
Number of pages20
JournalSeminars in Diagnostic Pathology
Issue number3
StatePublished - Sep 4 1997


  • Electron microscopy
  • Endocrine neoplasms
  • Germ-cell tumors
  • Immunohistochemistry
  • Malignant lymphomas
  • Neuroendoerine tumors
  • Renal cell carcinoma
  • Thymic carcinomas


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