TY - GEN
T1 - Classification of gene expression profiles
T2 - 8th International Conference on Hybrid Intelligent Systems, HIS 2008
AU - Rubio-Escudero, Cristina
AU - Martínez-Álvarez, Francisco
AU - Romero-Zaliz, Rocío
AU - Zwir, Igor
PY - 2008
Y1 - 2008
N2 - Biomedical research has been revolutionized by high-throughput techniques and the enormous amount of data they are able to generate. In particular technology has the capacity to monitor changes in RNA abundance for thousands of genes simultaneously. The interest shown over microarray analysis methods has rapidly raised. Clustering is widely used in the analysis of microarray data to group genes of interest targeted from microarray experiments on the basis of similarity of expression patterns. In this work we apply two clustering algorithms, K-means and Expectation Maximization to particular a problem and we compare the groupings obtained on the basis of the cohesiveness of the gene products associated to the genes in each cluster.
AB - Biomedical research has been revolutionized by high-throughput techniques and the enormous amount of data they are able to generate. In particular technology has the capacity to monitor changes in RNA abundance for thousands of genes simultaneously. The interest shown over microarray analysis methods has rapidly raised. Clustering is widely used in the analysis of microarray data to group genes of interest targeted from microarray experiments on the basis of similarity of expression patterns. In this work we apply two clustering algorithms, K-means and Expectation Maximization to particular a problem and we compare the groupings obtained on the basis of the cohesiveness of the gene products associated to the genes in each cluster.
UR - http://www.scopus.com/inward/record.url?scp=55349118862&partnerID=8YFLogxK
U2 - 10.1109/HIS.2008.92
DO - 10.1109/HIS.2008.92
M3 - Conference contribution
AN - SCOPUS:55349118862
SN - 9780769533261
T3 - Proceedings - 8th International Conference on Hybrid Intelligent Systems, HIS 2008
SP - 831
EP - 836
BT - Proceedings - 8th International Conference on Hybrid Intelligent Systems, HIS 2008
Y2 - 10 September 2008 through 12 September 2008
ER -