Abstract
Introduction: Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy participants. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans. Methods: To assess the force-frequency response, participants received single doses of CK-107 and placebo in a randomized, double-blind, 4-period, crossover study. The force-frequency response of foot dorsiflexion following stimulation of the deep fibular nerve to activate the tibialis anterior muscle was assessed. Results: CK-107 significantly increased tibialis anterior muscle response with increasing dose and plasma concentration in a frequency-dependent manner; the largest increase in peak force was ∼60% at 10 Hz. Discussion: CK-107 appears more potent and produced larger increases in force than tirasemtiv—a first-generation FSTA—in a similar pharmacodynamic study, thereby supporting its development for improvement of muscle function of patients. Muscle Nerve 57: 729–734, 2018.
Original language | English |
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Pages (from-to) | 729-734 |
Number of pages | 6 |
Journal | Muscle and Nerve |
Volume | 57 |
Issue number | 5 |
DOIs | |
State | Published - May 2018 |
Keywords
- CK-2127107
- fast skeletal muscle troponin activator
- force-frequency relationship
- phase 1
- skeletal muscle