TY - JOUR
T1 - Cisplatin-based combination chemotherapy for disseminated germ cell tumors
T2 - Long-term follow-up
AU - Roth, B. J.
AU - Greist, A.
AU - Kubilis, P. S.
AU - Williams, S. D.
AU - Einhorn, L. H.
PY - 1988
Y1 - 1988
N2 - A retrospective analysis of the initial 229 cases of disseminated germ cell tumors treated at Indiana University with cisplatin, vinblastine, and bleomycin (PVB), with or without doxorubicin revealed 146 pateints who are alive and disease-free with a minimum follow-up of 6 years and a median follow-up of 8.5 years. At 12 years, the estimated probability of survival is 65.0%, and the estimated probability of relapse-free survival for complete responders is 83.5%. Long-term complications, such as clinically significant organ toxicity or therapy-related second malignancies, have not been observed. The functional status of survivors is maintained, with 95% returning to their pretherapy status, of which 88% are fully employed. Of patients receiving chemotherapy without abdominal surgery, 35% have fathered healthy children posttherapy. Achievement of complete remision (CR) in disseminated germ cell tumors with cisplatin-based combination chemotherapy translates to long-term disease-free survival and cure for the majority of patients, with preservation of functional status.
AB - A retrospective analysis of the initial 229 cases of disseminated germ cell tumors treated at Indiana University with cisplatin, vinblastine, and bleomycin (PVB), with or without doxorubicin revealed 146 pateints who are alive and disease-free with a minimum follow-up of 6 years and a median follow-up of 8.5 years. At 12 years, the estimated probability of survival is 65.0%, and the estimated probability of relapse-free survival for complete responders is 83.5%. Long-term complications, such as clinically significant organ toxicity or therapy-related second malignancies, have not been observed. The functional status of survivors is maintained, with 95% returning to their pretherapy status, of which 88% are fully employed. Of patients receiving chemotherapy without abdominal surgery, 35% have fathered healthy children posttherapy. Achievement of complete remision (CR) in disseminated germ cell tumors with cisplatin-based combination chemotherapy translates to long-term disease-free survival and cure for the majority of patients, with preservation of functional status.
UR - http://www.scopus.com/inward/record.url?scp=0023748580&partnerID=8YFLogxK
U2 - 10.1200/JCO.1988.6.8.1239
DO - 10.1200/JCO.1988.6.8.1239
M3 - Article
C2 - 2457658
AN - SCOPUS:0023748580
SN - 0732-183X
VL - 6
SP - 1239
EP - 1247
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 8
ER -