Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America

Teresa C.T. Peret, Caroline B. Hall, Gregory W. Hammond, Pedro A. Piedra, Gregory A. Storch, Wayne M. Sullender, Cecilia Tsou, Larry J. Anderson

Research output: Contribution to journalArticlepeer-review

211 Scopus citations

Abstract

Human respiratory syncytial virus (HRSV) is a major cause of serious lower respiratory tract illness in infants, young children, and the elderly. To characterize the circulation patterns of HRSV strains, nucleotide sequencing of the C-terminal region of the G protein gene was performed on 34-53 isolates obtained from 5 communities during 1 epidemic year, representing distinct geographical locations in North America. Phylogenetic analysis revealed that 5-7 HRSV genotypes, including 1 or 2 predominant strains, circulated in each community. The patterns of genotypes were distinct between communities, and less diversity was seen between strains of the same genotype within than between communities. These findings are consistent with HRSV outbreaks' being community based in nature, although transmission of viruses between communities may occur. Several strains are probably introduced or circulate endemically in communities each year, and local factors - possibly immunity induced by previous years' strains - determine which strains predominate during an HRSV season.

Original languageEnglish
Pages (from-to)1891-1896
Number of pages6
JournalJournal of Infectious Diseases
Volume181
Issue number6
DOIs
StatePublished - 2000

Fingerprint Dive into the research topics of 'Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America'. Together they form a unique fingerprint.

Cite this