TY - JOUR
T1 - Circulating vitamin d metabolite levels in hypophosphatasia
AU - Whyte, Michael P.
AU - Seino, Yoshiki
PY - 1982/7
Y1 - 1982/7
N2 - 25OHD, 1,25-(OH)2D, and 24,25-(OH)2D were assayed in the serum of 16 patients with the infantile, childhood, or adult form of hypophosphatasia. Except for diminished 1,25- (OH)2D and elevated 24,25-(OH)2D levels in 2 infants (which could be attributed to nonparathyroid hormone-mediated hypercalcemia), the mean circulating level of each vitamin D metabolite was normal in the 3 patient groups. Abnormalities in vitamin D metabolism do not appear to contribute to the pathogenesis of this rare hereditary form of rickets or osteomalacia, which occurs despite normal circulating calcium, inorganic phosphate, and vitamin D metabolite levels.
AB - 25OHD, 1,25-(OH)2D, and 24,25-(OH)2D were assayed in the serum of 16 patients with the infantile, childhood, or adult form of hypophosphatasia. Except for diminished 1,25- (OH)2D and elevated 24,25-(OH)2D levels in 2 infants (which could be attributed to nonparathyroid hormone-mediated hypercalcemia), the mean circulating level of each vitamin D metabolite was normal in the 3 patient groups. Abnormalities in vitamin D metabolism do not appear to contribute to the pathogenesis of this rare hereditary form of rickets or osteomalacia, which occurs despite normal circulating calcium, inorganic phosphate, and vitamin D metabolite levels.
UR - http://www.scopus.com/inward/record.url?scp=0020450679&partnerID=8YFLogxK
U2 - 10.1210/jcem-55-1-178
DO - 10.1210/jcem-55-1-178
M3 - Article
C2 - 6978889
AN - SCOPUS:0020450679
SN - 0021-972X
VL - 55
SP - 178
EP - 180
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 1
ER -