Circulating vitamin d metabolite levels in hypophosphatasia

Michael P. Whyte, Yoshiki Seino

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

25OHD, 1,25-(OH)2D, and 24,25-(OH)2D were assayed in the serum of 16 patients with the infantile, childhood, or adult form of hypophosphatasia. Except for diminished 1,25- (OH)2D and elevated 24,25-(OH)2D levels in 2 infants (which could be attributed to nonparathyroid hormone-mediated hypercalcemia), the mean circulating level of each vitamin D metabolite was normal in the 3 patient groups. Abnormalities in vitamin D metabolism do not appear to contribute to the pathogenesis of this rare hereditary form of rickets or osteomalacia, which occurs despite normal circulating calcium, inorganic phosphate, and vitamin D metabolite levels.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number1
DOIs
StatePublished - Jul 1982

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