Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations > 25 nmol/L in children

Bridgit O. Crews; Jennifer Moore; Dennis J. Dietzen

doi:10.1515/jpem-2014-0012

Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations > 25 nmol/L in children

Bridgit O. Crews, Jennifer Moore, Dennis J. Dietzen

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7 Scopus citations

Abstract

Vitamin D status is best reflected by circulating concentrations of 25-hydroxyvitamin D₂and D₃(25-OHD). An adequate blood concentration of total 25-OH-D is commonly defined as that which maintains parathyroid hormone (PTH) within the normal range. Consensus from studies of adults with renal impairment indicates that 75 nmol/L of 25-OH-D maintains suppression of PTH. No similar consensus exists in children. We studied the correlation of PTH and 25-OH-D in 271 patients aged 2 months to 21 years (mean 11 years) in a tertiary care pediatric setting. Patients with renal impairment were excluded by elevated creatinine concentration and chart review. PTH did not significantly correlate with 25-OH-D concentrations > 25 nmol/L. PTH was significantly elevated in specimens with < 25 nmol/L of 25-OH-D (p = 10-17). Using PTH suppression as indicator, these data suggest that 25-OH-D concentrations > 25 nmol/L in children indicate vitamin D sufficiency.

Original language	English
Pages (from-to)	657-660
Number of pages	4
Journal	Journal of Pediatric Endocrinology and Metabolism
Volume	27
Issue number	7-8
DOIs	https://doi.org/10.1515/jpem-2014-0012
State	Published - Jul 1 2014

Keywords

Calcium
Parathyroid hormone
Renal failure
Rickets
Vitamin D

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title = "Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations > 25 nmol/L in children",

abstract = "Vitamin D status is best reflected by circulating concentrations of 25-hydroxyvitamin D2and D3(25-OHD). An adequate blood concentration of total 25-OH-D is commonly defined as that which maintains parathyroid hormone (PTH) within the normal range. Consensus from studies of adults with renal impairment indicates that 75 nmol/L of 25-OH-D maintains suppression of PTH. No similar consensus exists in children. We studied the correlation of PTH and 25-OH-D in 271 patients aged 2 months to 21 years (mean 11 years) in a tertiary care pediatric setting. Patients with renal impairment were excluded by elevated creatinine concentration and chart review. PTH did not significantly correlate with 25-OH-D concentrations > 25 nmol/L. PTH was significantly elevated in specimens with < 25 nmol/L of 25-OH-D (p = 10-17). Using PTH suppression as indicator, these data suggest that 25-OH-D concentrations > 25 nmol/L in children indicate vitamin D sufficiency.",

keywords = "Calcium, Parathyroid hormone, Renal failure, Rickets, Vitamin D",

author = "Crews, {Bridgit O.} and Jennifer Moore and Dietzen, {Dennis J.}",

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T1 - Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations > 25 nmol/L in children

AU - Crews, Bridgit O.

AU - Moore, Jennifer

AU - Dietzen, Dennis J.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Vitamin D status is best reflected by circulating concentrations of 25-hydroxyvitamin D2and D3(25-OHD). An adequate blood concentration of total 25-OH-D is commonly defined as that which maintains parathyroid hormone (PTH) within the normal range. Consensus from studies of adults with renal impairment indicates that 75 nmol/L of 25-OH-D maintains suppression of PTH. No similar consensus exists in children. We studied the correlation of PTH and 25-OH-D in 271 patients aged 2 months to 21 years (mean 11 years) in a tertiary care pediatric setting. Patients with renal impairment were excluded by elevated creatinine concentration and chart review. PTH did not significantly correlate with 25-OH-D concentrations > 25 nmol/L. PTH was significantly elevated in specimens with < 25 nmol/L of 25-OH-D (p = 10-17). Using PTH suppression as indicator, these data suggest that 25-OH-D concentrations > 25 nmol/L in children indicate vitamin D sufficiency.

AB - Vitamin D status is best reflected by circulating concentrations of 25-hydroxyvitamin D2and D3(25-OHD). An adequate blood concentration of total 25-OH-D is commonly defined as that which maintains parathyroid hormone (PTH) within the normal range. Consensus from studies of adults with renal impairment indicates that 75 nmol/L of 25-OH-D maintains suppression of PTH. No similar consensus exists in children. We studied the correlation of PTH and 25-OH-D in 271 patients aged 2 months to 21 years (mean 11 years) in a tertiary care pediatric setting. Patients with renal impairment were excluded by elevated creatinine concentration and chart review. PTH did not significantly correlate with 25-OH-D concentrations > 25 nmol/L. PTH was significantly elevated in specimens with < 25 nmol/L of 25-OH-D (p = 10-17). Using PTH suppression as indicator, these data suggest that 25-OH-D concentrations > 25 nmol/L in children indicate vitamin D sufficiency.

KW - Calcium

KW - Parathyroid hormone

KW - Renal failure

KW - Rickets

KW - Vitamin D

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SN - 0334-018X

VL - 27

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JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

IS - 7-8

ER -

Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations > 25 nmol/L in children

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