Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations > 25 nmol/L in children

Bridgit O. Crews, Jennifer Moore, Dennis J. Dietzen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Vitamin D status is best reflected by circulating concentrations of 25-hydroxyvitamin D2and D3(25-OHD). An adequate blood concentration of total 25-OH-D is commonly defined as that which maintains parathyroid hormone (PTH) within the normal range. Consensus from studies of adults with renal impairment indicates that 75 nmol/L of 25-OH-D maintains suppression of PTH. No similar consensus exists in children. We studied the correlation of PTH and 25-OH-D in 271 patients aged 2 months to 21 years (mean 11 years) in a tertiary care pediatric setting. Patients with renal impairment were excluded by elevated creatinine concentration and chart review. PTH did not significantly correlate with 25-OH-D concentrations > 25 nmol/L. PTH was significantly elevated in specimens with < 25 nmol/L of 25-OH-D (p = 10-17). Using PTH suppression as indicator, these data suggest that 25-OH-D concentrations > 25 nmol/L in children indicate vitamin D sufficiency.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume27
Issue number7-8
DOIs
StatePublished - Jul 1 2014

Keywords

  • Calcium
  • Parathyroid hormone
  • Renal failure
  • Rickets
  • Vitamin D

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