TY - JOUR
T1 - Circulating Biomarkers in Glioblastoma Ready for Prime Time?
AU - Mathios, Dimitrios
AU - Phallen, Jillian
N1 - Publisher Copyright:
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Liquid biopsy approaches for detection of circulating biomarkers of cancer have been utilized in oncology in many clinical settings from early detection to disease monitoring. Recent approaches have focused on circulating tumor cells, circulating tumor DNA, and circulating RNAs in a variety of biofluids. However, very little progress has been made in implementing such approaches for detection of brain tumors, despite the tremendous clinical need for earlier and less invasive diagnosis, as well as more accurate assessment of disease status. In this review, we highlight the recent methodological improvements in the field of liquid biopsy technologies specifically for glioblastoma. Although many retrospective and few prospective studies have been conducted to assess the utility of circulating biomarkers for detection of brain tumors, none have yet moved forward to clinical implementation.
AB - Liquid biopsy approaches for detection of circulating biomarkers of cancer have been utilized in oncology in many clinical settings from early detection to disease monitoring. Recent approaches have focused on circulating tumor cells, circulating tumor DNA, and circulating RNAs in a variety of biofluids. However, very little progress has been made in implementing such approaches for detection of brain tumors, despite the tremendous clinical need for earlier and less invasive diagnosis, as well as more accurate assessment of disease status. In this review, we highlight the recent methodological improvements in the field of liquid biopsy technologies specifically for glioblastoma. Although many retrospective and few prospective studies have been conducted to assess the utility of circulating biomarkers for detection of brain tumors, none have yet moved forward to clinical implementation.
KW - Circulating biomarker
KW - circulating RNAs
KW - circulating tumor cells
KW - circulating tumor DNA
KW - glioblastoma
KW - liquid biopsy
UR - http://www.scopus.com/inward/record.url?scp=85117286517&partnerID=8YFLogxK
U2 - 10.1097/PPO.0000000000000541
DO - 10.1097/PPO.0000000000000541
M3 - Review article
C2 - 34570455
AN - SCOPUS:85117286517
SN - 1528-9117
VL - 27
SP - 404
EP - 409
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 5
ER -