TY - JOUR
T1 - Circadian regulation of astrocyte function
T2 - implications for Alzheimer’s disease
AU - McKee, Celia A.
AU - Lananna, Brian V.
AU - Musiek, Erik S.
N1 - Funding Information:
This work was funded by NIH Grant R01AG054551.
Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The circadian clock regulates rhythms in gene transcription that have a profound impact on cellular function, behavior, and disease. Circadian dysfunction is a symptom of aging and neurodegenerative diseases, and recent studies suggest a bidirectional relationship between impaired clock function and neurodegeneration. Glial cells possess functional circadian clocks which may serve to control glial responses to daily oscillations in brain activity, cellular stress, and metabolism. Astrocytes directly support brain function through synaptic interactions, neuronal metabolic support, neuroinflammatory regulation, and control of neurovascular coupling at blood and CSF barriers. Emerging evidence suggests that the astrocyte circadian clock may be involved in many of these processes, and that clock disruption could influence neurodegeneration by disrupting several aspects of astrocyte function. Here we review the literature surrounding circadian control of astrocyte function in health and disease, and discuss the potential implications of astrocyte clocks for neurodegeneration.
AB - The circadian clock regulates rhythms in gene transcription that have a profound impact on cellular function, behavior, and disease. Circadian dysfunction is a symptom of aging and neurodegenerative diseases, and recent studies suggest a bidirectional relationship between impaired clock function and neurodegeneration. Glial cells possess functional circadian clocks which may serve to control glial responses to daily oscillations in brain activity, cellular stress, and metabolism. Astrocytes directly support brain function through synaptic interactions, neuronal metabolic support, neuroinflammatory regulation, and control of neurovascular coupling at blood and CSF barriers. Emerging evidence suggests that the astrocyte circadian clock may be involved in many of these processes, and that clock disruption could influence neurodegeneration by disrupting several aspects of astrocyte function. Here we review the literature surrounding circadian control of astrocyte function in health and disease, and discuss the potential implications of astrocyte clocks for neurodegeneration.
KW - Alzheimer’s disease
KW - Astrocyte
KW - Circadian rhythms
KW - Neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85073926711&partnerID=8YFLogxK
U2 - 10.1007/s00018-019-03314-y
DO - 10.1007/s00018-019-03314-y
M3 - Review article
C2 - 31578625
AN - SCOPUS:85073926711
SN - 1420-682X
VL - 77
SP - 1049
EP - 1058
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 6
ER -