Circadian pacemaker neurons display cophasic rhythms in basal calcium level and in fast calcium fluctuations

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Abstract

SignificanceDaily rhythms in the molecular clock, in calcium, and in electrical activity all interact to support the functions of circadian pacemaker neurons. However, the regulatory mechanisms that unify these properties are not defined. Here, we utilize the cellular resolution of the Drosophila circadian neural circuit with technological improvements in light-sheet imaging. We report that individual Drosophila pacemakers display two cophasic rhythms of daily calcium fluctuations. We previously described the first: slow changes in intracellular calcium. The second involves high-frequency calcium fluctuations that depend on the function of the T-type calcium channel. We propose that the fast rhythms, emerging sequentially across the 24-h day, correspond to spontaneous electrical activity patterns displayed by different pacemaker groups.

Original languageEnglish
Pages (from-to)e2109969119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number17
DOIs
StatePublished - Apr 26 2022

Keywords

  • Drosophila
  • ITPR
  • T-type calcium channel
  • calcium
  • circadian rhythms

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