Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells

Adam C. Silver, Alvaro Arjona, Michael E. Hughes, Michael N. Nitabach, Erol Fikrig

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen and splenic NK cells. The aim of our study was to investigate the existence of molecular clock mechanisms in other immune cells. Therefore, we measured the circadian changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages, dendritic cells, and B cells in both mice entrained to a light-dark cycle and under constant environmental conditions. Our study reveals the existence of functional molecular clock mechanisms in splenic macrophages, dendritic cells, and B cells.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalBrain, Behavior, and Immunity
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Keywords

  • B cells
  • Circadian rhythm
  • Dendritic cells
  • Gene expression
  • Macrophages

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