@article{66a6c1cda4544f2a8989c62d2166d08c,
title = "Circadian control of lung inflammation in influenza infection",
abstract = "Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the timing of influenza infection is not well understood. Here we demonstrate that endogenous rhythms affect survival in influenza infection. Circadian control of influenza infection is mediated by enhanced inflammation as proven by increased cellularity in bronchoalveolar lavage (BAL), pulmonary transcriptomic profile and histology and is not attributable to viral burden. Better survival is associated with a time dependent preponderance of NK and NKT cells and lower proportion of inflammatory monocytes in the lung. Further, using a series of genetic mouse mutants, we elucidate cellular mechanisms underlying circadian gating of influenza infection.",
author = "Shaon Sengupta and Tang, {Soon Y.} and Devine, {Jill C.} and Anderson, {Se{\'a}n T.} and Soumyashant Nayak and Zhang, {Shirley L.} and Alex Valenzuela and Fisher, {Devin G.} and Grant, {Gregory R.} and L{\'o}pez, {Carolina B.} and FitzGerald, {Garret A.}",
note = "Funding Information: We are thankful to members of the FitzGerald Lab−S. Teegarden for help with animal breeding and general lab management; Yasmine Issah and Amruta Naik for general animal husbandry and lab management; G. S. Worthen, A. Sehgal, and R. Simmons who were part of the Sengupta{\textquoteright}s K08 committee and to T. Kambayashi for advice on NK cell depletion. This work was supported by the NHLBI-K08HL132053 (S.S.), NICHD-K12HD043245 (S.S.), a Maturational Human Biology grant from the Institute of Translational Medicine and Therapeutics, University of Pennsylvania (S.S.), NIH/NIAID R01AI134862 and R01AI137062 (C.B.L.) and NIH/NCRR RR023567 (G.A.F.). G.A.F. is the McNeil Professor of Translational Medicine and Therapeutics and a senior advisor to Calico Laboratories. Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41467-019-11400-9",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
number = "1",
}