Ciprofloxacin overdose: Acute renal failure with prominent apoptotic changes

Vikas R. Dharnidharka, Kari Nadeau, Carolyn L. Cannon, H. William Harris, Seymour Rosen

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42 Scopus citations


Acute renal failure due to ciprofloxacin has been well described. The previously reported cases have been consistent both clinically and pathologically with tubulointerstitial nephritis (TIN). We report a case of ciprofloxalon overdose leading to acute renal failure characterized by acute tubular necrosis (ATN). The outstanding features in the patient's renal biopsy were those of distal nephron apoptosis, best seen in plastic-embedded sections and electron microscopy. This report shows that the distal nephron can be singularly involved in acute renal failure and that electron microscopy or plastic-embedded sections may be necessary to define its involvement.

Original languageEnglish
Pages (from-to)710-712
Number of pages3
JournalAmerican Journal of Kidney Diseases
Issue number4
StatePublished - Apr 1998


  • Acute renal failure
  • Apoptosis
  • Ciprofloxacin


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