Cingulo-opercular control network and disused motor circuits joined in standby mode

Dillan J. Newbold, Evan M. Gordon, Timothy O. Laumann, Nicole A. Seider, David F. Montez, Sarah J. Gross, Annie Zheng, Ashley N. Nielsen, Catherine R. Hoyt, Jacqueline M. Hampton, Mario Ortega, Babatunde Adeyemo, Derek B. Miller, Andrew N. Van, Scott Marek, Bradley L. Schlaggar, Alexandre R. Carter, Benjamin P. Kay, Deanna J. Greene, Marcus E. RaichleSteven E. Petersen, Abraham Z. Snyder, Nico U.F. Dosenbach

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.

Original languageEnglish
Article numbere2019128118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number13
DOIs
StatePublished - Mar 30 2021

Keywords

  • Disuse
  • FMRI
  • Network neuroscience
  • Plasticity
  • Spontaneous activity

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