Cingulo-opercular control network and disused motor circuits joined in standby mode

Dillan J. Newbold; Evan M. Gordon; Timothy O. Laumann; Nicole A. Seider; David F. Montez; Sarah J. Gross; Annie Zheng; Ashley N. Nielsen; Catherine R. Hoyt; Jacqueline M. Hampton; Mario Ortega; Babatunde Adeyemo; Derek B. Miller; Andrew N. Van; Scott Marek; Bradley L. Schlaggar; Alexandre R. Carter; Benjamin P. Kay; Deanna J. Greene; Marcus E. Raichle; Steven E. Petersen; Abraham Z. Snyder; Nico U.F. Dosenbach

doi:10.1073/pnas.2019128118

Cingulo-opercular control network and disused motor circuits joined in standby mode

Dillan J. Newbold, Evan M. Gordon, Timothy O. Laumann, Nicole A. Seider, David F. Montez, Sarah J. Gross, Annie Zheng, Ashley N. Nielsen, Catherine R. Hoyt, Jacqueline M. Hampton, Mario Ortega, Babatunde Adeyemo, Derek B. Miller, Andrew N. Van, Scott Marek, Bradley L. Schlaggar, Alexandre R. Carter, Benjamin P. Kay, Deanna J. Greene, Marcus E. RaichleSteven E. Petersen, Abraham Z. Snyder, Nico U.F. Dosenbach

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.

Original language	English
Article number	e2019128118
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	118
Issue number	13
DOIs	https://doi.org/10.1073/pnas.2019128118
State	Published - Mar 30 2021

Keywords

Disuse
FMRI
Network neuroscience
Plasticity
Spontaneous activity

Access to Document

10.1073/pnas.2019128118

Cite this

Newbold, D. J., Gordon, E. M., Laumann, T. O., Seider, N. A., Montez, D. F., Gross, S. J., Zheng, A., Nielsen, A. N., Hoyt, C. R., Hampton, J. M., Ortega, M., Adeyemo, B., Miller, D. B., Van, A. N., Marek, S., Schlaggar, B. L., Carter, A. R., Kay, B. P., Greene, D. J., ... Dosenbach, N. U. F. (2021). Cingulo-opercular control network and disused motor circuits joined in standby mode. Proceedings of the National Academy of Sciences of the United States of America, 118(13), Article e2019128118. https://doi.org/10.1073/pnas.2019128118

@article{6d958ae3d6d943bf89ab1bc45ab77450,

title = "Cingulo-opercular control network and disused motor circuits joined in standby mode",

abstract = "Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.",

keywords = "Disuse, FMRI, Network neuroscience, Plasticity, Spontaneous activity",

author = "Newbold, {Dillan J.} and Gordon, {Evan M.} and Laumann, {Timothy O.} and Seider, {Nicole A.} and Montez, {David F.} and Gross, {Sarah J.} and Annie Zheng and Nielsen, {Ashley N.} and Hoyt, {Catherine R.} and Hampton, {Jacqueline M.} and Mario Ortega and Babatunde Adeyemo and Miller, {Derek B.} and Van, {Andrew N.} and Scott Marek and Schlaggar, {Bradley L.} and Carter, {Alexandre R.} and Kay, {Benjamin P.} and Greene, {Deanna J.} and Raichle, {Marcus E.} and Petersen, {Steven E.} and Snyder, {Abraham Z.} and Dosenbach, {Nico U.F.}",

year = "2021",

month = mar,

day = "30",

doi = "10.1073/pnas.2019128118",

language = "English",

volume = "118",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "13",

}

Newbold, DJ, Gordon, EM , Laumann, TO, Seider, NA, Montez, DF, Gross, SJ, Zheng, A, Nielsen, AN, Hoyt, CR, Hampton, JM, Ortega, M, Adeyemo, B, Miller, DB, Van, AN, Marek, S, Schlaggar, BL, Carter, AR , Kay, BP, Greene, DJ, Raichle, ME, Petersen, SE, Snyder, AZ & Dosenbach, NUF 2021, 'Cingulo-opercular control network and disused motor circuits joined in standby mode', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 13, e2019128118. https://doi.org/10.1073/pnas.2019128118

TY - JOUR

T1 - Cingulo-opercular control network and disused motor circuits joined in standby mode

AU - Newbold, Dillan J.

AU - Gordon, Evan M.

AU - Laumann, Timothy O.

AU - Seider, Nicole A.

AU - Montez, David F.

AU - Gross, Sarah J.

AU - Zheng, Annie

AU - Nielsen, Ashley N.

AU - Hoyt, Catherine R.

AU - Hampton, Jacqueline M.

AU - Ortega, Mario

AU - Adeyemo, Babatunde

AU - Miller, Derek B.

AU - Van, Andrew N.

AU - Marek, Scott

AU - Schlaggar, Bradley L.

AU - Carter, Alexandre R.

AU - Kay, Benjamin P.

AU - Greene, Deanna J.

AU - Raichle, Marcus E.

AU - Petersen, Steven E.

AU - Snyder, Abraham Z.

AU - Dosenbach, Nico U.F.

PY - 2021/3/30

Y1 - 2021/3/30

N2 - Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.

AB - Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.

KW - Disuse

KW - FMRI

KW - Network neuroscience

KW - Plasticity

KW - Spontaneous activity

UR - http://www.scopus.com/inward/record.url?scp=85102977422&partnerID=8YFLogxK

U2 - 10.1073/pnas.2019128118

DO - 10.1073/pnas.2019128118

M3 - Article

C2 - 33753484

AN - SCOPUS:85102977422

SN - 0027-8424

VL - 118

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 13

M1 - e2019128118

ER -

Cingulo-opercular control network and disused motor circuits joined in standby mode

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this