@article{6d958ae3d6d943bf89ab1bc45ab77450,
title = "Cingulo-opercular control network and disused motor circuits joined in standby mode",
abstract = "Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.",
keywords = "Disuse, FMRI, Network neuroscience, Plasticity, Spontaneous activity",
author = "Newbold, {Dillan J.} and Gordon, {Evan M.} and Laumann, {Timothy O.} and Seider, {Nicole A.} and Montez, {David F.} and Gross, {Sarah J.} and Annie Zheng and Nielsen, {Ashley N.} and Hoyt, {Catherine R.} and Hampton, {Jacqueline M.} and Mario Ortega and Babatunde Adeyemo and Miller, {Derek B.} and Van, {Andrew N.} and Scott Marek and Schlaggar, {Bradley L.} and Carter, {Alexandre R.} and Kay, {Benjamin P.} and Greene, {Deanna J.} and Raichle, {Marcus E.} and Petersen, {Steven E.} and Snyder, {Abraham Z.} and Dosenbach, {Nico U.F.}",
note = "Funding Information: We thank Kristen M. Scheidter and Annie L. Nguyen for help in collecting MRI data and Ryan V. Raut for his comments on the manuscript. This work was supported by NIH Grants NS110332 (to D.J.N.), NS088590 (to N.U.F.D.), TR000448 (to N.U.F.D.), MH124567 (to N.U.F.D.), MH096773 (to N.U.F.D.), MH122066 (to N.U.F.D.), MH1000872 (to T.O.L.), MH112473 (to T.O.L.), NS090978 (to B.P.K.), MH104592 (to D.J.G.), NS080675 (to M.E.R.), and NS098577 (to the Neuroimaging Informatics and Analysis Center); US Department of Veterans Affairs Clinical Sciences Research and Development Service Grant 1IK2CX001680 (to E.M.G.); the Kiwanis Neuroscience Research Foundation (N.U.F.D.); Jacobs Foundation Grant 2016121703 (to N.U.F.D.); the Child Neurology Foundation (N.U.F.D.); the McDonnell Center for Systems Neuroscience (D.J.N., T.O.L., A.Z., B.L.S., and N.U.F.D.); the McDonnell Foundation (S.E.P.); Mallinckrodt Institute of Radiology Grant 14-011 (to N.U.F.D.); and the Hope Center for Neurological Disorders (N.U.F.D., B.L.S., and S.E.P.). Publisher Copyright: {\textcopyright} 2021 National Academy of Sciences. All rights reserved.",
year = "2021",
month = mar,
day = "30",
doi = "10.1073/pnas.2019128118",
language = "English",
volume = "118",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "13",
}